Tuberc Respir Dis.  2007 Oct;63(4):323-330.

The Effect of Smoking on Lung Function

• Lee KH

Abstract

No abstract available.

MeSH Terms

Lung*
Smoke*
Smoking*
Smoke

Figure

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  Figure 1 Predicted and observed annual rates of change of height-adjusted FEV1 for men and women. The circles and error bars represent the mean ± 95% confidence interval of the observed annual rate of loss of height-adjusted FEV1 for subjects grouped by former smokers (mean packs/day = 0) and continued smokers divided into three subgroups by tertiles of mean packs/day. The dashed line connects the means predicted from the longitudinal model.

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  Figure 2 Decline in FEV1 during 10 years in men and women by smoking habits (never = never smoker, ex = ex-smoker, smoker = current smoker) and age at start of the observation period adjusted for family history of old and socio-economic class in a multiple linear regression model.

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  Figure 3 Comparison of geometric mean and SEM PC20 values and baseline FEV1% pred between smokers and ex-smokers in 1982 and 1986. The open symbols represent measurements in 1982 and the closed symbols the 1986 values. The asterisks indicate a significant fall in both FEV1% pred and PC20 in smokers over this period according to paired t tests.

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  Figure 4 The cumulative percentage of the study population responding with a 20% fall in FEV1 is shown for each of the sequential methacholine concentrations that were administered. The shift of the cumulative distribution upward and to the left indicates that there was an overall increase in responsiveness to methacholine during the study interval.

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  Figure 5 The mean change in AR (ie, LMCR) is plotted against the change in FEV1 over the 5-year interval. Separate plots are made for each smoking category. The continuous-smoking group is shifted to the left, indicating a greater decline in FEV1 compared to the group of sustained quitters. The continuous-smoking group is shifted upward, indicating a tendency for a greater increase in AR for a given decline in FEV1. The effect of changes in FEV1, however, has greater influence on changes in AR than does smoking status.

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  Figure 6 Mean postbronchodilator forced expiratory volume at 1 second (FEV1) for participants in the smoking intervention and placebo group who were sustained quitters (open circles) and continuous smokers (closed circles). The two curves diverge sharply after baseline.

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  Figure 7 Mean postbronchodilator forced expiratory volume at 1 second (FEV1) over the course of the study in all participants in whom the measurement was made. Circles/dotted line represent the smoking intervention and placebo group, triangles/solid lines represent the smoking intervention and ipratropium bromide group, and squares/dashed line represent the usual care group.

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  Figure 8 Lung function improved during Year 1 among quitters, but declined among continuing smokers. The subsequent rate of decline is twice as great among continuing smokers as among sustained quitters. Those who relapsed lost function and those who delayed quitting benefited regardless of when they quit.

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  Figure 9 Distribution of average annual rates of FEV1 change over 6 yr by smoking status. Numbers along X-axis are midpoints of the FEV1 change intervals. The solid line represents continuous smokers and the dashed line represents never smokers.

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  Figure 10 Mean FEV1, values in non-smokers (NN), consistent ex-smokers (XX), subjects who quit smoking during follow-up (SQ), and consistent smokers (SS) in several age groups. Data for men are shown in top panel and those for women in bottom panel. Numbers of subjects in each category are shown in parentheses.

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  Figure 11 Age-adjusted relative risk of hospitalization for chronic obstructive pulmonary disease (COPD) by pack years among smokers who inhaled, in the Copenhagen City Heart Study (CCHS). Note the logarithmic scale. M: male; F: female.

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  Figure 12 Proportion of subjects in the Bronchial Obstruction in the Nord Trondelag study sample reporting respiratory symptoms by forced expiratory volume in one second (FEV1) % predicted in males (–) and females (——), adjusted by age and pack-yrs. □: wheeze or breathlessness; ●: daily cough in periods; ◆: chronic bronchitis.

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