Tuberc Respir Dis.  2004 Jul;57(1):55-60.

A Case of Anticonvulsant Hypersensitivity Syndrome with Subcarinal Lymph node Enlargement and Eosinophilic Pneumonia Induced by Carbamazepine

• Jeon IS
• Jang JY
• Park JE
• Song CY
• Jung CW
• Kim SH
• Kang KW

Abstract

Anticonvulsant hypersensitivity syndrome (AHS) is an uncommon, but potentially fatal and mutilsystemic disorder that occurs after exposure to the arene oxide-producing anticonvulsants-carbamzepine, phenobarbital and phenytoin. The multisystemic reactions include fever, skin eruptions, lymphadenopathy, hematologic abnormality and hepatitis. The diagnosis of AHS is made by history of drug exposure and clinical course. No specific treatments are proved as benefit except discontinuing the offending drug and trying the steroids in some severe cases. We report a case of carbamazepine induced anticonvulsant hypersensitivity syndrome characterized by skin rash, eosinophilia, subcarinal lymphadenopathy and eosinophilic pneumonia. The patient was resolved completely after only discontinuing carbamazepine.

Keyword

Anticonvulsant hypersensitivity syndrome; Carbamazepine; Eosinophilic pneumonia

MeSH Terms

Carbamazepine*
Diagnosis
Eosinophilia
Eosinophils*
Exanthema
Fever
Hepatitis
Humans
Hypersensitivity*
Lymph Nodes*
Lymphatic Diseases
Phenobarbital
Phenytoin
Pulmonary Eosinophilia*
Skin
Steroids
Carbamazepine
Phenobarbital
Phenytoin
Steroids