Korean J Med.  2006 Jun;70(6):617-626.

Prevalence and clinical characteristics of microalbuminuria in Koreans: a population-based cross-sectional study

• Kim ER
• Sung KC
• Chon CU
• Kwon CH
• Koh YL
• Lee HJ
• Park SK
• Lee DY
• Yun JH
• Kim BJ
• Kim BS
• Kang JH
• Lee MH
• Park JR
• Ryu SH

Abstract

BACKGROUND: Microalbuminuria (MA) is independent predictor of cardiovascular disease and it cause mortality regardless of the presence of diabetes (DM) and hypertension (HTN). However, few published studies on this topic have been reported in Korea. Therefore, we investigated the MA prevalence and relationship between MA, insulin resistance and cardiovascular risk factor.
METHODS
A total of 5,915 (3,053 men and 2,852 women) health screen examinees were enrolled in this study. We measured the anthropometric and biochemical parameters of the atherogenic indexes.
RESULTS
The MA prevalence was 7.7% in all participants. The prevalence of MA in the men and women was 9.5% and 5.7%, respectively. Elevated levels of serum fasting glucose, serum fasting insulin, HOMA index, total cholesterols, LDL cholesterol, TG, Body Mass Index (BMI) and the systolic and diastolic blood pressure were significantly associated with MA. The results of multiple logistic regression analysis about MA showed that frequent drinking, low BMI, newly diagnosed DM and elevated levels of HOMA index and blood pressure were significantly associated with MA prevalence. Also, excluding newly diagnosed diabetic and hypertensive subjects, the MA prevalence was 5.7% (6.9% in men, 4.7% in women) and in multiple logistic regression analysis, the MA prevalence significantly increased in the individuals with pre-HTN rather than in the normotensives.
CONCLUSIONS
The MA prevalence was 7.7% in all subjects. Except the newly diagnosed diabetic and hypertensive subjects, it was 5.7%. The MA prevalence was significantly increased in the individuals with pre-HTN rather than in the normotensives and MA was related with insulin resistance.

Keyword

Microalbuminuria; Hypertension; Prehypertension; Insulin resistance

MeSH Terms

Blood Pressure
Body Mass Index
Cardiovascular Diseases
Cholesterol
Cholesterol, LDL
Cross-Sectional Studies*
Drinking
Fasting
Female
Glucose
Humans
Hypertension
Insulin
Insulin Resistance
Korea
Logistic Models
Male
Mortality
Prehypertension
Prevalence*
Risk Factors
Cholesterol
Cholesterol, LDL
Glucose
Insulin