Korean J Biol Psychiatry.  2006 Nov;13(4):260-266.

No Associations between Schizophrenia and D22S280 Marker on Synapsin III Gene in Korean Males

• Lee YS
• Park CW
• Lee SY
• Lee SJ
• Park YB
• Shin YS
• Yoo JK
• Hong KS
• Yang BH

Abstract

OBJECTIVES
Synapsin III near VCFS region on chromosome 22q affects. It could be an interesting candidate gene for schizophrenia. D22S280 is a highly polymorphic genetic marker residing in synapsin III. We examined association of D22S280 marker on synapsin III with Korean patients with schizophrenia.
METHODS
The subjects were 46 male Korean patients with schizophrenia and 60 male normal controls. Using polymerase chain reaction, gel electrophoresis, ABI 310 genetic analyzer, and GeneScan Collection 3.1 software, we confirmed genotypes of D22S280 marker. We examined Hardy-Weinberg equilibrium and case-control association using SAS/Genetic 9.1.3.
RESULTS
Genotypes of both schizophrenia and control groups were in Hardy-Weinberg equilibrium. We could not find any significant statistical differences in allele-wise(chi-square=10.4, df=6, p=0.098) and genotype-wise (chi-square=22.1 df=19, p=0.258) analyses of D22S280 marker between schizophrenia and normal controls. Individual allele analyses with df=1 showed significant differences in A1(p=0.025) and A7(p=0.034) allele, which were not significant following Bonferroni corrections(A1 : p=0.177, A7 : p=0.235).
CONCLUSION
We couldn't find any association between schizophrenia and the synapsin III gene. Given the small number of subjects studied, further investigations are needed.

Keyword

Schizophrenia; ynapsin III; 22S280; ssociation

MeSH Terms

Alleles
Case-Control Studies
Electrophoresis
Genetic Markers
Genotype
Humans
Male*
Polymerase Chain Reaction
Schizophrenia*
Synapsins*
Genetic Markers
Synapsins