Korean J Pathol.  1992 Apr;26(2):191-196.

Carcinosarcoma of the Esophagus: A report of case

Affiliations
  • 1Department of Clinical Pathology, Catholic University Medical College, Seoul, Korea.

Abstract

Carcinosarcoma of the esophagus is a rare neoplasm composed of both carcinoma and spindle sarcomatous area. Usually the carcinoma component is a squamous cell carcinoma but rarely adenocarcinoma or undifferentiated carcinoma is found. The histogenesis of the sarcomatous component is still unknown. A case of ulcerated polypoid lesion with a stalk in esophagus was reported. Microscopically it was composed of spindle shaped cells interminled with squamous cell carcinoma and small cell carcinoma nests. No distinct transition between spindle shaped cells and carcinoma are was observed. Immunoreactivity to cytokeratin was observed in both carcinomatous and spindle cell component, but electron microscopic examination failed to demonstrated desmosome or tonofilaments in spindle cells. Undifferentiated small cell nests were reactive to neuron specific enolase and contained membrane bounded secretory granule in electron microscopy.

Keyword

Carcinosarcoma; Pseudosarcoma; Small cell carcinoma; Esophagus

MeSH Terms

Adenocarcinoma
Carcinoma
Carcinoma, Small Cell
Carcinoma, Squamous Cell
Carcinosarcoma*
Cellular Structures
Desmosomes
Esophagus*
Intermediate Filaments
Keratins
Membranes
Microscopy, Electron
Phosphopyruvate Hydratase
Secretory Vesicles
Ulcer
Keratins
Phosphopyruvate Hydratase
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