Allergy Asthma Immunol Res.  2010 Apr;2(2):61-64. 10.4168/aair.2010.2.2.61.

Prevalence of Childhood Asthma in Korea: International Study of Asthma and Allergies in Childhood

• Lee SI

• KMID: 2260591
• DOI: http://doi.org/10.4168/aair.2010.2.2.61

Abstract

Childhood asthma is a major concern because it leads to more hospital visits and a heavy economic burden. Proper management and prevention strategies for childhood asthma must be based on correct evaluation of prevalence and risk factors for its development. In Korea, nationwide studies were conducted in 1995 and 2000 on students from 68 elementary schools (age, 6-12 years) and junior high schools (age, 12-15 years) by the Korean Academy of Pediatric Allergy and Respiratory Diseases. We used the Korean version of the International Study of Asthma and Allergies in Childhood (ISAAC) written and video questionnaires at the same schools during the same period (October-November). The prevalence of asthma in junior high school children seemed to increase over 5 years. However, in elementary school children, the prevalence of asthma symptoms decreased, although the prevalence of 'diagnosis of asthma, ever' and 'treatment of asthma, last 12 months' increased. In addition, it was found that various factors, such as obesity, passive smoking, dietary habits, raising pets at home, and fever/antibiotic use during infancy were associated with childhood asthma. When prevalence of asthma in Korea was compared with that in different regions, the prevalence changes in the 6-7 years age group did not seem to be consistent between regions, whereas similar trends were observed among children aged 13-14 years. To conduct another epidemiological study to evaluate the time trend over time, a third nationwide survey is planned in 2010, and we anticipate ISAAC Phase 3 will explore recent changes in the prevalence of childhood asthma and assess its risk factors in Korean children. On the basis of accurate data on the current status of childhood asthma in 2010, we will be able to establish proper management strategies.

Keyword

Asthma; child; Korea

MeSH Terms

Aged
Asthma
Child
Epidemiologic Studies
Food Habits
Humans
Hypersensitivity
Korea
Obesity
Prevalence
Risk Factors
Tobacco Smoke Pollution
Surveys and Questionnaires
Tobacco Smoke Pollution

Figure

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  Fig. 1 Prevalence of asthma by the written questionnaire survey in elementary school children (6-12 years).

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  Fig. 2 Prevalence of asthma by the written questionnaire survey in junior high school children (12-15 years).

Reference

1. Stewart AW, Mitchell EA, Pearce N, Strachan DP, Weiland SK. The relationship of per capita gross national product to the prevalence of symptoms of asthma and other atopic diseases in children (ISAAC). Int J Epidemiol. 2001. 30:173–179.

2. Strachan DP, Cook DG. Health effects of passive smoking. 6. Parental smoking and childhood asthma: longitudinal and case-control studies. Thorax. 1998. 53:204–212.

3. Nordling E, Berglind N, Melen E, Emenius G, Hallberg J, Nyberg F, Pershagen G, Svartengren M, Wickman M, Bellander T. Traffic-related air pollution and childhood respiratory symptoms, function and allergies. Epidemiology. 2008. 19:401–408.

4. Hirshon JM, Shardell M, Alles S, Powell JL, Squibb K, Ondov J, Blaisdell CJ. Elevated ambient air zinc increases pediatric asthma morbidity. Environ Health Perspect. 2008. 116:826–831.

5. Ryan PH, Lemasters GK, Biswas P, Levin L, Hu S, Lindsey M, Bernstein DI, Lockey J, Villareal M, Khurana Hershey GK, Grinshpun SA. A comparison of proximity and land use regression traffic exposure models and wheezing in infants. Environ Health Perspect. 2007. 115:278–284.

6. Morgenstern V, Zutavern A, Cyrys J, Brockow I, Koletzko S, Kramer U, Behrendt H, Herbarth O, von Berg A, Bauer CP, Wichmann HE, Heinrich J. Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children. Am J Respir Crit Care Med. 2008. 177:1331–1337.

7. von Mutius E. Infection: friend or foe in the development of atopy and asthma? The epidemiological evidence? Eur Respir J. 2001. 18:872–881.

8. Weiland SK, Husing A, Strachan DP, Rzehak P, Pearce N. Climate and the prevalence of symptoms of asthma, allergic rhinitis, and atopic eczema in children. Occup Environ Med. 2004. 61:609–615.

9. Weiland SK, von Mutius E, Husing A, Asher MI. ISAAC Steering Committee. Intake of trans fatty acids and prevalence of childhood asthma and allergies in Europe. Lancet. 1999. 353:2040–2041.

10. Ellwood P, Asher MI, Bjorksten B, Burr M, Pearce N, Robertson CF. ISAAC Phase One Study Group. Diet and asthma, allergic rhinoconjunctivitis and atopic eczema symptom prevalence: an ecological analysis of the International Study of Asthma and Allergies in Childhood (ISAAC) data. Eur Respir J. 2001. 17:436–443.

11. Chinn S, Rona RJ. Can the increase in body mass index explain the rising trend in asthma in children? Thorax. 2001. 56:845–850.

12. Schaub B, von Mutius E. Obesity and asthma, what are the links? Curr Opin Allergy Clin Immunol. 2005. 5:185–193.

13. Hong SJ, Lee MS, Lee SY, Ahn KM, Oh JW, Kim KE, Lee JS, Lee HB. High body mass index and dietary pattern are associated with childhood asthma. Pediatr Pulmonol. 2006. 41:1118–1124.

14. Ahn KM, Lee MS, Hong SJ, Lim DH, Ahn YM, Lee HR, Lee MI, Lee MH, Shin YK, Kim KE. Fever, use of antibiotics, and acute gastroenteritis during infancy as risk factors for the development of asthma in Korean school-age children. J Asthma. 2005. 42:745–750.

15. Illi S, von Mutius E, Lau S, Niggemann B, Gruber C, Wahn U. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet. 2006. 368:763–770.

16. Burr ML, Emberlin JC, Treu R, Cheng S, Pearce NE. Pollen counts in relation to the prevalence of allergic rhinoconjunctivitis, asthma and atopic eczema in the International Study of Asthma and Allergies in Childhood (ISAAC). Clin Exp Allergy. 2003. 33:1675–1680.

17. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet. 1998. 351:1225–1232.

18. Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK, Williams H. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 2006. 368:733–743.

19. Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med. 2006. 355:2226–2235.

20. Lee SI, Shin MH, Lee HB, Lee JS, Son BK, Koh YY, Kim KE, Ahn YO. Prevalences of symptoms of asthma and other allergic diseases in korean children: a nationwide questionnaire survey. J Korean Med Sci. 2001. 16:155–164.

21. Hong SJ, Kim SW, Oh JW, Rah YH, Ahn YM, Kim KE, Koh YY, Lee SI. The validity of the ISAAC written questionnaire and the ISAAC video questionnaire (AVQ 3.0) for predicting asthma associated with bronchial hyperreactivity in a group of 13-14 year old Korean schoolchildren. J Korean Med Sci. 2003. 18:48–52.

22. Hong SJ, Lee MS, Sohn MH, Shim JY, Han YS, Park KS, Ahn YM, Son BK, Lee HB. Self-reported prevalence and risk factors of asthma among Korean adolescents: 5-year follow-up study, 1995-2000. Clin Exp Allergy. 2004. 34:1556–1562.

23. Hong SJ. Korean ISAAC Study Group of Korean Association of Allergy and Respiratory Diseases. Report of Korean ISAAC epidemiologic study for asthma and allergic diseases in children. Pediatr Allergy Respir Dis. 2007. 17:Suppl 1. S55–S66.

24. Pearce N, Ait-Khaled N, Beasley R, Mallol J, Keil U, Mitchell E, Robertson C. Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax. 2007. 62:758–766.