Korean J Anesthesiol.  1994 Oct;27(10):1474-1480. 10.4097/kjae.1994.27.10.1474.

Anaphylactoid Reaction to Atracurium

Affiliations
  • 1Department of Anesthesiology, Hanil Hospital, Seoul, Korea.
  • 2Department of Internal Medicine, Seoul National University, College of Medicine, Seoul, Korea.

Abstract

A case is reported of anaphylactoid reaction to atracurium, used for the induetion of an- esthesia for skin graft in a 36 year old man. The patient had no previous history of any allergic tendency. It is not possible to distinguish between direct pharmacological effects and immune mediated hypersensitivity reactions by clinical observation alone. The mechanism of reaction in this patient was investigated by the leukocyte histamine release test, intradermal test, direct intravenous challenge with other induction agents used during the induction of anesthesia and radioallergosorbent test. The histamine releasing property of atracurium, the distinguishing methods between ana phylactic and anaphylatoid reaction, and the anesthetic management for this kind of reaction are discussed.

Keyword

Atracurium; Anaphylaxis; Anaphylactoid reaction

MeSH Terms

Adult
Anaphylaxis
Anesthesia
Atracurium*
Histamine
Histamine Release
Humans
Hypersensitivity
Intradermal Tests
Leukocytes
Radioallergosorbent Test
Skin
Transplants
Atracurium
Histamine
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