Korean J Anesthesiol.  1996 May;30(5):610-614. 10.4097/kjae.1996.30.5.610.

The Effect of Clonidine Administered with Bupivacaine in Brachial Plexus Block

• Yoon CS
• Choi JH
• Cho SK
• Han SM
• Suh BT

• KMID: 2239104
• DOI: http://doi.org/10.4097/kjae.1996.30.5.610

Abstract

BACKGROUND: Clonidine, a alpha2-receptor agonist, has sedative and decrease the MAC of anesthetics. Clonidine also has analgesic properties following intrathecal administration. This study evaluates the effects of clonidine on the onset time and duration of analgesia when added to bupivacaine for brachial plexus block.
METHODS
Forty patients of ASA physical ststus 1 and 2I who scheduled for elective upper limb surgery were divided into two groups in randomized, double-bline fashion. The brachial plexus block was performed with 30 ml of 0.33% bupivacaine plus saline(1ml; n=20)or clonidine(150ug, 1ml; n=20). The following variables were recorded; onset time, duration of analgesia, sedation, heart rate and blood pressure.
RESULTS
The onset time produced with the addition of clonidine was faster(15.6+/-5 vs 19+/-4 min). The duration of block, heart rate and blood pressure were not different between the groups. There were more sedation in the clonidine group.
CONCLUSIONS
From the above results, adding clonidine to bupivacaine is an attractive adjuvants for brachial plexus block.

Keyword

Anesthetic techniques; regional; brachial plexus; Anesthetics; local; Pharmacology; clonidine

MeSH Terms

Analgesia
Anesthetics
Blood Pressure
Brachial Plexus*
Bupivacaine*
Clonidine*
Heart Block
Heart Rate
Humans
Pharmacology
Upper Extremity
Anesthetics
Bupivacaine
Clonidine