Korean J Anesthesiol.  1997 Oct;33(4):627-632. 10.4097/kjae.1997.33.4.627.

The Effects of Intranasal Midazolam on Preanesthetic Sedation in Children

• Kim YJ
• Kim CO
• Kim YH
• Son SC

• KMID: 2237718
• DOI: http://doi.org/10.4097/kjae.1997.33.4.627

Abstract

BACKGROUND
S: This study was performed to determine the onset time and dose of intranasal midazolam used for preanesthetic sedation in children.
METHODS
The children were randomly allocated to recieve one of three medications via the nasal route in a double blind manner. Group I: patients were given normal saline 0.2 ml/5kg, Group II: patients were given midazolam 0.2 mg/kg, Group III: patients were given midazolam 0.3 mg/kg.
RESULTS
The cardiovascular and SpO2 changes were not significantly different among the patients of the three groups. The sedation score was greater in group II compared with group I from 5 minute after administration (1.9 vs 2.7, p<0.05). postanesthetic recovery score (PARS) was not significantly different among the three groups.
CONCLUSIONS
It is suggested that intranasal midazolam (0.2 mg/kg) produces anxiolysis and sedation in children with rapid onset.

Keyword

Age factors, children; Anesthesia, pediatric; Anesthetic technique, intranasal; Premedication, midazolam

MeSH Terms

Child*
Humans
Midazolam*
Midazolam