Korean J Dermatol.  1988 Feb;26(1):22-27.

A Study of Topical Corticosteroid Effect on the Rat Skin Mast Cell

• Kim SH
• Lee ES
• Chang CY

Abstract

The effect of long-term topical application of corticosteroids on rat cutaneous mast cells was examined under the light microscopy. Two potent corticosteroids, 0.05% clobetasol-17-propionate and 0.25% desoxymethasone, produced a remarkable decresse greater than 50% of pretreatment mast cell number by two weeks. Wheress a less potent corticosteroid, 0.1% hydrocotisone-17-valerate, produced a remarkable decrease greater than 50% of pretreatment mast cell number by four weeks. All corticosteroids produced a remarkable decrease greater than 80% of pretreatment mast cell number by six weeks. These results suggest that long-term topical application of corticosteroids may have the deleterious effects on cutsneous mast cells.

Keyword

Mast Cell; Corticosteroid

MeSH Terms

Adrenal Cortex Hormones
Animals
Desoximetasone
Mast Cells*
Microscopy
Rats*
Skin*
Adrenal Cortex Hormones
Desoximetasone