J Korean Ophthalmol Soc.  2009 Sep;50(9):1326-1333. 10.3341/jkos.2009.50.9.1326.

Photodynamic Therapy With Verteporfin using Half Fluence for Chronic Central Serous Chorioretinopathy

• Chang MH
• Kim SW
• Oh JR
• Huh K

• KMID: 2212615
• DOI: http://doi.org/10.3341/jkos.2009.50.9.1326

Abstract

PURPOSE
To evaluate the clinical results of half-fluence photodynamic therapy (PDT) using verteporfin in patients with chronic central serous chorioretinopathy (CSC). METHODS: The author reviewed the charts of 20 patients (22 eyes) who underwent PDT for chronic central serous chorioretinopathy. All 22 eyes were treated using an irradiance of 300 mW over 83 second (25 J/cm2). Postoperative evaluation included improvements in visual acuity, complications, changes in central macular thickness with the optical coherence tomogram (OCT), and recurrence. RESULTS: The best-corrected visual acuity improved significantly from 0.50+/-0.32 to 0.12+/-0.19 logMAR at 3 months (p<0.01), and the mean central macular thickness decreased from 377.7+/-86.3 micrometer to 166.2+/-29.3 micrometer at 3 months (p<0.01). Exudative serous macular detachments were resolved completely in all eyes within 3 months. There was no recurrence after PDT during the follow-up period. CONCLUSIONS: PDT using half fluence appeared to be a beneficial treatment option for patients with chronic CSC. Further studies are needed to verify treatment safety as well as the time and rate of recurrences.

Keyword

Chronic central serous chorioretinopathy; Half fluence photodynamic therapy

MeSH Terms

Central Serous Chorioretinopathy
Eye
Follow-Up Studies
Humans
Photochemotherapy
Porphyrins
Recurrence
Triazenes
Visual Acuity
Porphyrins
Triazenes

Figure

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  Figure 1. The left eye of a 38-year-old man (No. 8) (Table 1) with chronic central serous chorioretinopathy (CSC) showing a submacular neurosensory retinal detachment (A) and focal retinal pigment epithelium (RPE) leakage (B). (C) The baseline OCT showing a neurosensory retinal detachment in the macular region. (D) Red-free fundus photography taken 3 months after PDT showing no submacular neurosensory retinal detachment. (E) Late phase FA taken 3 months after PDT showing no angiogenic leakage. (F) The OCT image obtained at 3 months showing complete resolution of the subretinal fluid.

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  Figure 2. The right eye of a 48-year-old man (No. 6) (Table 1) with chronic central serous chorioretinopathy (CSC) showing a submacular neurosensory retinal detachment (A) and focal retinal pigment epithelium (RPE) leakage (B). (C) The baseline OCT showing a neurosensory retinal detachment in the macular region. (D) Red-free fundus photograph taken 3 months after PDT showing no submacular neurosensory retinal detachment. (E) Late phase FA taken 3 months after PDT demonstrating the absence of fluorescein leakage at macula with window defect at the fovea. (F) The OCTimage obtained at 3 months showing complete resolution of the subretinal fluid.

Reference

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