J Bone Metab.  2018 Nov;25(4):235-241. 10.11005/jbm.2018.25.4.235.

Age-related Reference Intervals for Total Collagen-I-N-terminal Propeptide in Healthy Korean Population

Affiliations
  • 1Department of Orthopaedic Surgery, Gyeongsang National University Hospital, Jinju, Korea.
  • 2Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
  • 3Department of Laboratory Medicine, Aerospace Medical Center, Republic of Korea Air Force, Cheongju, Korea.
  • 4Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
  • 5Department of Laboratory Medicine, Gyeongsang National University College of Medicine, Jinju, Korea.
  • 6Department of Laboratory Medicine, Jeju National University Hospital, Jeju, Korea.
  • 7Department of Orthopaedic Surgery, Chung-Ang University College of Medicine, Seoul, Korea. hayongch@naver.com

Abstract

BACKGROUND
Procollagen type I N-terminal propeptide (PINP) is one of the most clinically useful bone formation biomarkers. Therefore, the purpose of this study was to independently evaluate the performance of automated total PINP assay and established age- and gender-specific reference intervals for PINP in healthy Korean population.
METHODS
The imprecision, linearity, and detection capability of Elecsys total PINP assay was determined and reference interval was established using 599 serums from Korean population with normal bone mineral densities based on bone densitometry. Age groups were divided into 20s, 30s, 40s, 50s, 60s and over.
RESULTS
Elecsys total PINP had excellent performance in imprecision, linearity, and detection capability. When partitioning age groups in Korean male and female populations, there was significant difference in total PINP between different age groups. In male populations, PINP level was decreased with increasing age, then it remained steady after middle-age. In female populations, there was a decreasing tendency similar to that in the male population with a sharp increase in the 50 to 59 age group.
CONCLUSIONS
Elecsys total PINP assay showed precise and reliable performance in our study. We established age-related PINP reference intervals for Korean male and female population with normal bone mineral densities.

Keyword

Osteogenesis; Peptide fragments; Procollagen; Procollagen type I N-terminal peptide; Reference values

MeSH Terms

Biomarkers
Bone Density
Collagen Type I
Densitometry
Female
Humans
Male
Osteogenesis
Peptide Fragments
Procollagen
Reference Values
Biomarkers
Collagen Type I
Peptide Fragments
Procollagen

Figure

  • Fig. 1 Linearity curve of measured values of procollagen type I N-terminal propeptide compared to expected values.

  • Fig. 2 Age-related distribution of P1NP values in healthy Korean males (A) and females (B). Boxes represent inter-quartile range (bold bar, median). Whiskers extend to 5th and 95th percentile. P1NP, procollagen type I N-terminal propeptide.


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