J Korean Neurol Assoc.  2016 Feb;34(1):45-48. 10.17340/jkna.2016.1.8.

Reversible Leukoencephlaopathy Caused by Doxifluridine in a Patient with Gastric Cancer

Affiliations
  • 1Departments of Neurology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea. jsk120@hanmail.net
  • 2Pharmacology and Pharmacogenomics Research Center, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Abstract

Doxifluridine neurotoxicity is more rare than 5-FU neurotoxicity. We report a case of leukoencephalopathy caused by long-term use of doxifluridine and which was resolved after discontinuation. A 37-year-old woman who had been on doxifluridine for 4 months after gastrectomy presented with dysarthria. Diffusion-weighted MRI imaging revealed multifocal hyperintense lesions in subcortical areas. Her symptoms disappeared after discontinuing doxifluridine, and lesions on follow-up MRI were resolved. These findings suggest that doxifluridine is a plausible cause of reversible leukoencephalopathy.

Keyword

Doxifluridine; Reversible leukoencephalopathy; Neurotoxicity

MeSH Terms

Adult
Dysarthria
Female
Fluorouracil
Follow-Up Studies
Gastrectomy
Humans
Leukoencephalopathies
Magnetic Resonance Imaging
Stomach Neoplasms*
Fluorouracil
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