J Gynecol Oncol.  2008 Jun;19(2):135-138. 10.3802/jgo.2008.19.2.135.

Clinical characteristics of struma ovarii

Affiliations
  • 1Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea. cpobgy@hanmail.net

Abstract


OBJECTIVE
To evaluate the clinical characteristics of struma ovarii.
METHODS
Twenty-five cases of struma ovarii were reviewed retrospectively from June 1994 to April 2007. The presenting clinical, radiologic, and pathologic features of the patients were reviewed.
RESULTS
The mean age of the patients in this study was 45.3 years. The majority was of premenopausal status. Sixteen patients had clinical symptoms such as low abdominal pain, palpable abdominal mass and vaginal bleeding. Although one patient had an abnormal thyroid function test, the laboratory findings normalized after operative treatment. CA-125 levels were elevated in 6 cases. Diagnosis by preoperative imaging studies were 8 dermoid cysts, while only 3 cases were diagnosed as struma ovarii. There were 4 cases of malignant struma ovarii, and no patients with recurrent disease.
CONCLUSION
Struma ovarii is a rare tumor. The presented clinical, laboratory and radiological findings of patients are very diverse. The diagnosis was confirmed by pathologic findings. The treatment of benign struma ovarii is surgical resection only. The cases of malignant struma ovarii may need adjuvant treatment, but recurrence is uncommon.

Keyword

Struma ovarii; Dermoid tumor; Malignancy

MeSH Terms

Abdominal Pain
Dermoid Cyst
Humans
Recurrence
Retrospective Studies
Struma Ovarii
Thyroid Function Tests
Uterine Hemorrhage

Cited by  1 articles

Clinical Manifestations of Malignant Struma Ovarii: A Retrospective Case Series in a Tertiary Hospital in Korea
Hyun Jin Ryu, Da Eun Leem, Ji Hyun Yoo, Tae Hyuk Kim, Sun Wook Kim, Jae Hoon Chung
Endocrinol Metab. 2024;39(3):461-467.    doi: 10.3803/EnM.2023.1863.


Reference

1. Kempers RD, Dockerty MB, Hoffmann DL, Bartholomew LG. Struma ovarii: Ascitic, hyperthyroid and asymptomatic syndromes. Ann Intern Med. 1970. 72:883–893.
2. Willemse PH, Oosterhuis JW, Aalders JG, Piers DA, Sleijfer DT, Vermey A, et al. Malignant struma ovarii treated by ovariectomy, thyroidectomy, and 131 I administration. Cancer. 1987. 60:178–182.
3. Kim SJ, Pak K, Lim HJ, Yun KH, Seong SJ, Kim TJ, et al. Clinical diversity of struma ovarii. Korean J Obstet Gynecol. 2002. 45:748–752.
4. Boettlin R. Uber zahnentwickelung in dermoid cysten des ovariums. Virchows Arch Path Arat. 1889. 115:493–504.
5. Gottschalk S. Ein neuer typus einer kleincystischen bosartigen eierstockgeschwulst. Arch Gynak. 1899. 59:676–698.
6. Gould SF, Lopez RL, Speers WC. Malignant struma ovarii. A case report and literature review. J Reprod Med. 1983. 28:415–419.
7. Teilum G. Teilum G, editor. Struma ovarii. Special Tumors of Ovary and Testis. 1971. Philadelphia: J.B. Lippincott;166.
8. Bhansali A, Jain V, Rajwanshi A, Lodha S, Dash RJ. Follicular carcinoma in a functioning struma ovarii. Postgrad Med J. 1999. 75:617–618.
9. Zalel Y, Seidman DS, Oren M, Achiron R, Gotlieb W, Mashiach S, et al. Sonographic and clinical characteristics of struma ovarii. J Ultrasound Med. 2000. 19:857–861.
10. March DE, Desai AG, Park CH, Hendricks PJ, Davis PS. Struma ovarii hyperthyroidism in a postmenopausal women. J Nucl Med. 1998. 29:263–265.
11. Jang KH, Kim YT, Ryu HS, Kwon HC, Lee EJ, Lee HC, et al. Clinical diversity of struma ovarii. Korean J Obstet Gynecol. 1997. 40:1683–1689.
12. Ayhan A, Yanik F, Tuncer R, Tuncer ZS, Ruacan S. Struma ovarii. Int J Gynaecol Obstet. 1993. 42:143–146.
13. Marcus CC, Marcus SL. Struma ovarii. A report of 7 cases and a review of the subject. Am J Obstet Gynecol. 1961. 81:752–762.
14. Smith FG. Pathology and physiology of struma ovarii. Arch Surg. 1946. 53:603–626.
15. Leung YC, Hammond IG. Limitation of CA 125 in the pre-operative evaluation of a pelvic mass: Struma ovarii and ascites. Aust NZ J Obstet Gynaecol. 1993. 33:216–217.
16. O'Connell ME, Fisher C, Harmer CL. Malignant struma ovarii: Presentation and management. Br J Radiol. 1990. 63:360–363.
17. Pardo-Mindan FJ, Vazquez JJ. Malignant struma ovarii: Light and electrion micrdscopic study. Cancer. 1983. 51:337–343.
18. Ihalagama IR, Hewavisenthi SJ, Wijesinghe PS. Pregnancy following treated malignant struma ovarii. Ceylon Med J. 2004. 49:90–91.
19. DeSimone CP, Lele SM, Modesitt SC. Malignant struma ovarii: A case report and analysis of cases reported in the literature with focus on survival and I131 therapy. Gynecol Oncol. 2003. 89:543–548.
20. Sun LQ, Zhou FN, Guo LH. Struma ovarii: Analysis of a series of 9 cases and review of the literature. Int J Gynecol Cancer. 2006. 16:698.
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