Korean J Dermatol.  1998 Jun;36(3):528-531.

A Case of Spindle Cell Lipoma

Abstract

Spindle cell lipoma was first described in 1975 by Enzinger and Harvey as a variant of lipomas. Histopathological findings show the lipomatous tissue to be replaced by a mixture of uniform spindle cells and mature fat cells closely associated with a mucoid matrix and a varying number of collagen fibers. Immunohistochemical staining is reported to give assistance in the differential diagnosis af spindle cell lipoma from other fibrous or neural tumors. Also, it can be used to investigate the origin of the spindle cells. We report a case of spindle cell lipoma in a 41-year-old female. She had a solitary, normal skin colored, bean sized, subcutaneous mass on the forearm. Most of the spindle cells were strongly positive for vimentin, CD34 and NSE, but negative for actin, factor VIII, S-100 protein and neuro- filaments. The tumor was excised. No recurrence was recognized in a 10 month follow up period.


MeSH Terms

Actins
Adipocytes
Adult
Collagen
Diagnosis, Differential
Factor VIII
Female
Follow-Up Studies
Forearm
Humans
Lipoma*
Recurrence
S100 Proteins
Skin
Vimentin
Actins
Collagen
Factor VIII
S100 Proteins
Vimentin
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