J Korean Ophthalmol Soc.  1991 Jul;32(7):550-556.

Retinal Toxicity of Repetitive Intravitreal Injections of Amphotericin B

• Lee BJ
• Oum BS

Abstract

Authors evaluated the retinal toxic reation of intravitreal injection with a regimens of 10 microgram of amphotericin B on both phakic and aphakic eyes of rabbits. In addition to the eye receiving single injection, the effects of repeating the same dose second and third time at interval of 1 week were examined by light microscopy after last injection. The results were as follows: 1. Even a single intravitreal injection with regimens of 10 microgram amphotericin B, vitreous opacities and posterior subcapsular lens opacities were observed ophthalmoscopically. 2. A single and repeated intravitreal injections with regimens of 10 microgram amphotericin B showed focal areas of retinal toxic reation. 3. Lens extraction did not modify the retinotoxic reation of intravitreally administrated amphotericin B. 4. Repetitive intravitreal injection of amphotericin B did not show increasing retinal toxic reation.

Keyword

Amphotericin B; Intravitreal injections; Retinal toxicity

MeSH Terms

Amphotericin B*
Cataract
Intravitreal Injections*
Microscopy
Rabbits
Retinaldehyde*
Amphotericin B
Retinaldehyde