Korean J Anesthesiol.  1996 Nov;31(5):624-628. 10.4097/kjae.1996.31.5.624.

Continuous Intravenous Infusion of Propofol and Succinylcholine Supplemented with Nitrous Oxide in Short Duration of Microlaryngeal Surgery Comparison with Thiopental/Enflurane-N2O and Succinylcholine Infusion

• Lee HW
• Chae BK
• Choi JO
• Chang SH

• KMID: 2091026
• DOI: http://doi.org/10.4097/kjae.1996.31.5.624

Abstract

BACKGROUND: Anesthetic technique for laryngeal microscopic surgery should be focused on rapid recovery of deep anesthesia and full muscle relaxation. This study was taken to evaluate the effect of continuous infusion of propofol and succinylcholine for this kind of anesthetic goal.
METHODS
Forty patients scheduled for laryngeal microscopic surgery of short duration(15 min) were randomly allocated into two groups. Anesthesia was induced and maintained with either propofol(2.5 mg/kg followed by a continuous infusion of 0.1 mg/kg/min) in group P or with thiopental (5.0 mg/kg) and inhalation of 1~2 vol % enflurane for maintenance of anesthesia in group T/E. Succinylcholine(1 mg/kg followed by continuous infusion of 0.1 mg/kg/min) was administered to facilitate tracheal intubation and maintain neuromuscular blockade.
RESULTS
No significant difference of duration of anesthesia appeared between two groups. Additional doses of succinylcholine were needed in 10% of group P and 30% of group T/E (p<0.05). In group P, time to response to suction catheter(136+/-54 vs 232+/-116 sec), time to eye open spontaneously or to verbal commands (368+/-142 vs 549+/-165 sec) and time to extubation (454+/-117 vs 647+/-181 sec) were significantly shorter comparing to group T/E. The quality of awakening was more favorable in group P(p<0.05). Laryngeal suspension induced bradycardia in 15% of group P and in 5% of group T/E. Both group P and group T/E (10% vs 30%) needed esmolol infusion to control the blood pressure during surgical procedure.
CONCLUSIONS
Rapid recovery of anesthesia and muscle relaxation can be expected after continuous infusion of propofol(2.5 mg/kg followed by 0.1mg/kg/min) and succinylcholine(1 mg/kg followed by 0.1 mg/kg/min) supplemented with 50% N2O in 50% O2 for short duration of laryngeal microscopic surgery.

Keyword

Anesthetics,intravenous propofol; Anesthetics; volatile enflurane; Neuromuscular relaxant succinylcholine; Anesthetic Technique intravenous

MeSH Terms

Anesthesia
Anesthetics
Blood Pressure
Bradycardia
Enflurane
Humans
Infusions, Intravenous*
Inhalation
Intubation
Muscle Relaxation
Neuromuscular Blockade
Nitrous Oxide*
Propofol*
Succinylcholine*
Suction
Thiopental
Anesthetics
Enflurane
Nitrous Oxide
Propofol
Succinylcholine
Thiopental