J Korean Rheum Assoc.  1996 Jan;3(1):41-49.

Association of Antiphospholipid Antibodies and Thrombosis in Patients with Systemic Lupus Erythematosus

• Park SH
• Choi BS
• Cho YS
• Yang HI
• Hong YS
• Lee SH
• Cho CS
• Kim HY

Abstract

OBJECTIVE
To investigate the association of antiphosphoilpid antibodies with thrombosis and to evaluate the clinical usefulness of anticardiolipin isotypes measurement in patients with systemic lupus erythematosus (SLE).
METHODS
We examined the prevalence of IgG, IgM and IgA anticardiolipin antibod (aCL) isotypes measured by ELISA assay and lupus anticoagulant (LA) measured by kaolin clotting time in 158 patients.
RESULTS
The prevalence of aCL and their IgM and IgA isotypes were 43.7%, 24. 7%, 17. 7% and 17. 1% respectively. The prevalence of LA was 7.8%. The presence of IgG aCL (81,81%, odds ratio(OR)=17.55, p (0.001) and LA (45.45%, OR=16.67, p ( 0. 001) were significantly associated with thrombosis. A regression analysis showed that IgG aCL (OR=13.62, p=0.002) and LA (OR=10.59, p=0. 002) were also associated with thrombosis.
CONCLUSION
Our results suggest that the detection and serial monitoring of IgG aCL is a useful tool for diagnosis of thrombotic complication due to antiphosholipid antibodies in SLE.

Keyword

Systemic lups erythematosus; thrombosis; anticardiolipin antibodies; lupus anticoagulant

MeSH Terms

Antibodies
Antibodies, Anticardiolipin
Antibodies, Antiphospholipid*
Diagnosis
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Kaolin
Lupus Coagulation Inhibitor
Lupus Erythematosus, Systemic*
Prevalence
Thrombosis*
Antibodies
Antibodies, Anticardiolipin
Antibodies, Antiphospholipid
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Kaolin
Lupus Coagulation Inhibitor