J Korean Neurosurg Soc.  2001 Jan;30(1):5-11.

The Role of Basic Fibroblast Growth Factor in Moyamoya Disease

• Kim DS
• Choi JU
• Kim SH
• Yang KH
• Kim HS

Abstract

OBJECTIVES
AND OMPORTANCE: The present study investigated the levels of basic fibroblast growth factor(bFGF) in the CSF of patients with moyamoya disease and its clinical significance.
METHODS
The levels of bFGF in CSF, taken from 26 hemispheres of 14 moyamoya patients and 20 patients without vascular anomaly(control group), were measured by an enzyme-linked immunosorbent assay. We analyzed the correlation between the level of bFGF and the clinical factors such as age, onset pattern, development of neovascularization, and cerebral circulation.
RESULTS
The CSF of moyamoya patients contained a high concentration of bFGF to a significant extent. The bFGF level was apparently elevated in the patients in whom neovascularization from indirect revascularization, such as modified encephalo-duro-arterio-synangiosis(EDAS) was well developed. A linear correlation between the values of bFGF and clinical progression was noted.
CONCLUSIONS
The elevation of bFGF in moyamoya disease seems to be specific. Clinically, the bFGF level may be considered a useful indicator to predict the efficacy of indirect revascularization.

Keyword

Angiogenesis; Basic fibroblast growth factor; Encephalo-duro-arterio-synangiosis; Moyamoya disease

MeSH Terms

Enzyme-Linked Immunosorbent Assay
Fibroblast Growth Factor 2*
Fibroblasts
Humans
Moyamoya Disease*
Fibroblast Growth Factor 2