J Korean Soc Biol Psychiatry.  1997 Jun;4(1):121-126.

Changes of Psychopathology and Extrapyramidal Symptoms When Co-administering Fluoxetine and Haloperidol

• Lee MS
• Han CS
• Kim JW
• Won KS
• Kwak DL

Abstract

OBJECTIVES
The authors have intended to know the drug interaction of fluoxetine and haloperidol when coadministering two drugs to the chronic schizophrenics by assessing the changes of positive, negative symptoms and extrapyramidal symptoms. METHOD: We selected 38 patients, the chronic schizophrenics with no physical problems. they are randomly assigned to placebo group and drug group. And then, placebo or fluoxetine 20mg were administered to the subjects of each group during 8 week period. We have assessed their psychopathology and extrapyramidal symptoms using positive and Negative Syndrome Scale(PANSS), Clinical Global Impression(CGI), Simpson-Angus Scale at o, 2, 4, 6, 8 week during the period.
RESULTS
38 patients have completed the study during 8 week. 1) PANSS, CGI : no significant difference between groups and no significant change according to the times. 2) Simpson-Angus Scale : no significant changes.
CONCLUSION
When co-administering fluoxetine and haloperidol, there were no significant changes of psychopathology and extrapyramidal symptoms. There results suggest that it is safe to coadminister fluoxetine to schizophrenic with haloperidol treatment.

MeSH Terms

Drug Interactions
Fluoxetine*
Haloperidol*
Humans
Psychopathology*
Fluoxetine
Haloperidol