Korean J Dermatol.  1996 Aug;34(4):555-560.

Angiocentric T - cell Lymphoma: Clinical and Histopathologic Features of Four Patients

• Chi DH
• Suh HS
• Choi JH
• Sung KJ
• Huh JR
• Koh JK

Abstract

BACKGROUND: Angiocentric T-cell lymphoma(AL) is a rare subtype of cutaneous T-cell lymphoma and recently many cases have been reported from Taiwan and Japan. But little is known about the clinical and histopathologic features of AL and few data are available in Korea.
OBJECTIVE
Our purpose was to characterize the clinical and histopathologic features of the specific cutaneous manifestauons of AL and to investigate the association with Epstein-Barr virus (EBV).
METHODS
Clinical records and histopathologic evaluation of skin biopsy specimens from four patients with AL were reviewed. We also performed immunohistochemical staining using monoclonal antibodies against, surface markers of lymphocytes and in situ hybridization for EBV-encoded RNA(EBER) in lesional skin.
RESULTS
1. The most common clinical finding in our patients was indurated plaque predominantly on the trunk. 2. The common histopathologic finding in skin biopsy specimens from all four patients was angiocentric, angioinvasive, and angiodestructive infiltrate containing atypical lymphocytes. 3. In three of four patients, EBER was demonstrated in lesional skin by in situ hybridization.
CONCLUSION
AL is an unique clinicopathologic entity showing strong association with EBV in Korea.

Keyword

Angiocentric T-cell Lymphoma; Epstein-Barr Virus

MeSH Terms

Antibodies, Monoclonal
Biopsy
Herpesvirus 4, Human
Humans
In Situ Hybridization
Japan
Korea
Lymphocytes
Lymphoma*
Lymphoma, T-Cell, Cutaneous
Skin
T-Lymphocytes
Taiwan
Antibodies, Monoclonal