Korean J Anesthesiol.  2002 Dec;43(6):755-762. 10.4097/kjae.2002.43.6.755.

The Effects of Ketorolac Used for Postoperative Analgesia on Hemostatic Function: A Thromboelastographic Evaluation

• Choe IB
• Ko SH
• Kim DC
• Han YJ
• Choe H
• Min GC

• KMID: 1860638
• DOI: http://doi.org/10.4097/kjae.2002.43.6.755

Abstract

BACKGROUND: Thromboelastography (TEG) has recently become popular for assessment of whole blood coagulation in the operating room. Ketorolac, a potent injectable nonsteroidal anti-inflammatory drug (NSAID), is commonly used for postoperative analgesia. NSAID inhibit platelet aggregation in coagulation process. This study was designed to determine whether ketorolac used for postoperative analgesia can affect hemostatic function using a TEG.
METHODS
Seventy-four female patients, ASA physical status 1 or 2, scheduled for an elective gynecologic surgery were randomly allocated into one of four groups (Group 1: n = 10, control without patient-controlled analgesia (PCA); Group 2: n = 21, PCA with morphine 60 mg; Group 3: n = 20, PCA with morphine 30 mg + ketorolac 90 mg; Group 4: n = 23, PCA with ketorolac 180 mg). Blood samples were obtained for TEG analysis preoperatively and 24, 48 and 72 h after surgery. Cumulative drug dosage, visual analog pain scale, satisfaction degree and side effects were measured at 24, 48 and 72 h after surgery.
RESULTS
There were no significant differences in TEG parameters among the four groups at each time. There were no significant differences in visual analog pain scales and satisfaction degrees among the three groups using PCA for postoperative analgesia. Among the three groups using PCA for postoperative analgesia, Group 2 experienced more side effects.
CONCLUSIONS
Ketorolac does not affect hemostatic function for 3 days after surgery when administrated as a PCA drug.

Keyword

Hemostasis; ketorolac; postoperative; pain; thromboelastography

MeSH Terms

Analgesia*
Analgesia, Patient-Controlled
Blood Coagulation
Female
Gynecologic Surgical Procedures
Hemostasis
Humans
Ketorolac*
Morphine
Operating Rooms
Pain Measurement
Passive Cutaneous Anaphylaxis
Platelet Aggregation
Thrombelastography
Ketorolac
Morphine