J Korean Radiol Soc.  2004 Jun;50(6):433-436. 10.3348/jkrs.2004.50.6.433.

Double Contrast Media enhanced MRI with Ferumoxides-Gadolinium on Hepatocellular Carcinoma

• Choi SH

• KMID: 1833817
• DOI: http://doi.org/10.3348/jkrs.2004.50.6.433

Abstract

PURPOSE
To evaluate the effects of Ferumoxides on Gadolinium (Gd) enhanced dynamic liver magnetic resonance imaging (MRI) in cirrhotic patients and also for the diagnosis of hepatocellular carcinoma (HCC).
MATERIALS AND METHODS
29 patients with liver cirrhosis were examined at 1.5T. 12 patients had HCC. The imaging protocol included GE T1 in and opposed phases, and a breath-hold TSE T2 before and 30-60 min following 0.05 ml/kg Ferumoxides. Four dynamic in-phase GE series were also acquired after an injection of 20 ml of Gd at 2 ml/sec. SNR and CNR were calculated for liver lesion relative to the muscle and background liver respectively. Statistical analysis was performed using the paired t-test.
RESULTS
The SNR of the liver decreased by 8.6+/-1.20 (p<0.001) after Ferumoxides injection. At the peak of the Gd effect, the liver increased by 6.09+/-1.15 relative to the post Ferumoxides, but it was not significantly different from the pre-Ferumoxides study (p<0.01). Although there was no significant change in post Ferumoxides SNR of HCC, CNR of HCC relative to the liver increased by 7.54+/-1.61 (p<0.05). After the Gd injection, CNR of HCC increased by 15.6+/-3.87 (p<0.05).
CONCLUSION
The administration of Ferumoxides made HCC CNR increase, and it canceled the effect of Gd enhancement of the cirrhotic liver. The combination of Ferumoxides and Gd makes HCC CNR increase.

Keyword

Abdomen, MR; Liver, cirrhosis; Liver, MR; Liver neoplasms, MR; Magnetic resonance (MR), contrast media

MeSH Terms

Carcinoma, Hepatocellular*
Contrast Media*
Diagnosis
Gadolinium
Humans
Liver
Liver Cirrhosis
Magnetic Resonance Imaging*
Contrast Media
Gadolinium