J Korean Med Sci.  2012 Mar;27(3):243-249. 10.3346/jkms.2012.27.3.243.

Obesity Phenotype and Coronary Heart Disease Risk as Estimated by the Framingham Risk Score

• Park YS
• Kim JS

• KMID: 1792993
• DOI: http://doi.org/10.3346/jkms.2012.27.3.243

Abstract

There are conflicting data as to whether general or abdominal obesity is a better predictor of cardiovascular risk. This cross-sectional study involved 4,573 subjects aged 30 to 74 yr who participated in the Fourth Korea National Health and Nutrition Examination Survey conducted in 2008. Obesity phenotype was classified by means of body mass index (BMI) and waist circumference (WC), and participants were categorized into 4 groups. Individuals' 10-yr risk of coronary heart diseases (CHD) was determined from the Framingham risk score. Subjects with obese WC had a higher proportion of high risk for CHD compared to the normal WC group, irrespective of BMI level. Relative to subjects with normal BMI/normal WC, the adjusted odds ratios (ORs) of normal BMI/obese WC group (OR 2.93 [1.70, 5.04] and OR 3.10 [1.49, 6.46]) for CHD risk in male were higher than obese BMI/obese WC group (OR 1.91 [1.40, 2.61] and OR 1.70 [1.16, 2.47]), whereas the adjusted ORs of obese BMI/obese WC group (OR 1.94 [1.24, 3.04] and OR 3.92 [1.75, 8.78]) were higher than the others in female. Subjects with obese BMI/normal WC were not significantly associated with 10-yr CHD risk in men (P = 0.449 and P = 0.067) and women (P = 0.702 and P = 0.658). WC is associated with increased CHD risk regardless of the level of BMI. Men with normal BMI and obese WC tend to be associated with CHD risk than those with obese BMI and obese WC.

Keyword

Obesity; Body Mass Index; Waist Circumference; Cardiovascular Disease; Coronary Heart Disease; KNHANES

MeSH Terms

Adult
Aged
Body Mass Index
Coronary Disease/epidemiology/*etiology
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Nutrition Surveys/statistics & numerical data
Obesity/*complications/epidemiology/*pathology
Odds Ratio
Phenotype
Republic of Korea/epidemiology
Risk Factors
Waist Circumference

Figure

• 

  Fig. 1 Framingham risk score category within the obesity phenotype groups according to body mass index and waist circumference by gender (P < 0.001 across obesity phenotype groups). Normal BMI, 18.5 ≤ BMI < 25.0 (kg/m2); Obese BMI, BMI ≥ 25.0 kg/m2; Normal WC, WC < 90 cm in men or < 80 cm in women; Obese WC, WC ≥ 90 cm in men or ≥ 80 cm in women. BMI, body mass index; WC, waist circumference.

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