Korean Circ J.  1999 Mar;29(3):298-305. 10.4070/kcj.1999.29.3.298.

Beneficial Effects of Estrogen in Syndrome X of Postmenopausal Women

• Kim D
• Byun KH
• Kwon HM
• Yoon YW
• Hong BK
• Song KS
• Kim HS

• KMID: 1751682
• DOI: http://doi.org/10.4070/kcj.1999.29.3.298

Abstract

BACKGROUND
There are many reports about the correlation between cardiovascular disorders and estrogen deficiency in postmenopausal women. The purpose of current study is to know that postmenopausal estrogen therapy may affect the lipid metabolism and endogenous fibrinolytic system and exercise tolerance. METHOD: We investigated the relation of estrogen treatment (srogen 0.625 mg/day) to serum lipid levels, angiotensin converting enzyme activity, plasminogen activator inhibitor-1 and parameters of treadmill test in 22 postmenopausal women of normal coronary artery with abnormal exercise test complained with chest pain accompanied by postmenopausal symptoms.
RESULTS
Estrogen treatment significantly elevated the serum HDL-cholesterol level (42.8 to 50.1 mg/dl, p<0.05) and reduced the PAI-1 level (16.2 to 10.4 ng/dl, p<0.01) without considerable side effects. During the exercise test, the positivity appearance time and total exercise duration is significantly increased after estrogen treatment.
CONCLUSION
The postmenopausal use of estrogen favorably changed the lipid level, fibrinolytic system and might improve the microcirculation which may protect against the ischemic heart disease risk without significant side effects.

Keyword

Estrogen; Postmenopause

MeSH Terms

Chest Pain
Coronary Vessels
Estrogens*
Exercise Test
Exercise Tolerance
Female
Humans
Lipid Metabolism
Microcirculation
Myocardial Ischemia
Peptidyl-Dipeptidase A
Plasminogen Activator Inhibitor 1
Plasminogen Activators
Postmenopause
Estrogens
Peptidyl-Dipeptidase A
Plasminogen Activator Inhibitor 1
Plasminogen Activators