Clin Exp Reprod Med.  2011 Dec;38(4):179-185. 10.5653/cerm.2011.38.4.179.

Hormonal regulation of uterine chemokines and immune cells

• Park DW
• Yang KM

• KMID: 1743673
• DOI: http://doi.org/10.5653/cerm.2011.38.4.179

Abstract

The ultimate function of the endometrium is to allow the implantation of a blastocyst and to support pregnancy. Cycles of tissue remodeling ensure that the endometrium is in a receptive state during the putative 'implantation window', the few days of each menstrual cycle when an appropriately developed blastocyst may be available to implant in the uterus. A successful pregnancy requires strict temporal regulation of maternal immune function to accommodate a semi-allogeneic embryo. To preparing immunological tolerance at the onset of implantation, tight temporal regulations are required between the immune and endocrine networks. This review will discuss about the action of steroid hormones on the human endometrium and particularly their role in regulating the inflammatory processes associated with endometrial receptivity.

Keyword

Immunology; Endometrium; Immune tolerance; Sex steroid hormone; Inflammation; Blastocyst; Embryo; Chemokine; Implantation window; Human

MeSH Terms

Blastocyst
Chemokines
Dietary Sucrose
Embryonic Structures
Endometrium
Female
Humans
Immune Tolerance
Inflammation
Menstrual Cycle
Pregnancy
Social Control, Formal
Uterus
Chemokines
Dietary Sucrose