Korean J Dermatol.  1980 Jun;18(3):241-245.

Drug Eruption & Liver Damage due to Diaminodiphenyl - Sulfone (DDS): Report of a case

• Park YK
• Lee WH
• Tak MJ

Abstract

We report a case of drug eruption and liver damage due to diaminodiphenyl suIfone(DDS) ingestion in a 17-year-old female. This patient had taken DDS for 20 days, 100mg-200mg daily to treat an unknown skin disease. Thereafter, she had generalized erythematous eruption on whole body, icteric sclera and fever. Liver function test showed abnormality (SGOT 514 unit, SGPT 710 unit, alkarine phosphotase 4. 3 B.U., total biIirubin 7. Oml/dl, direct bilirubin 4. 8mg/dl). The adverse reactiions to DDS are gastrointestinal intolerance, hemolytic, anemia, methemoglobinemia, agranulocytoais, hepatitis, neuritis, psychosis and a skin rash described as a fixed drug eruption, erythema multiforme, exfoliative dermatitis and toxic epidermal necrolysis. In Korea, DDS has been used for the treatment of skin diseases of various types for a long time without prescription, especially in rural areas. This trend is a significant sociomediical problem in Korea.

MeSH Terms

Adolescent
Alanine Transaminase
Anemia
Bilirubin
Dermatitis, Exfoliative
Drug Eruptions*
Eating
Erythema Multiforme
Exanthema
Female
Fever
Hepatitis
Humans
Korea
Liver Function Tests
Liver*
Methemoglobinemia
Neuritis
Prescriptions
Psychotic Disorders
Sclera
Skin Diseases
Stevens-Johnson Syndrome
Alanine Transaminase
Bilirubin