Korean J Nucl Med.  2003 Aug;37(4):254-259.

99mTc-DTPA Galactosyl Human Serum Albumin Scintigraphy in Mushiroom Poisoning Patient: Comparison with Liver Ultrasonography

• Jeong SY
• Lee J
• Bae JH
• Chun KA
• Ahn BC
• Kang YM
• Jeong JM
• Lee KB

Abstract

99mTc-galactosyl human serum albumin (Tc-GSA) is a radiopharmaceutical that binds to asialoglycoprotein receptors, which are specifically present in the hepatocyte membrane. Because these receptors are decreased in hepatic parenchymal damage, the degree of Tc-GSA accumulation in the liver correlates with findings of liver function test. Hepatic images were performed with Tc-GSA in patients with acute hepatic dysfunction by Amantia Subjunquillea poisoning, and compared with these of liver ultrasonography (USG). Tc-GSA (185 MBq, 3 mg of GSA) was injected intravenously, and dynamic images were recorded for 30 minutes. Time-activity curves for the heart and liver were generated from regions of interest for the whole liver and precordium. Degree of hepatic uptake and clearance rate of Tc-GSA were generated by visual interpretation and semiquantitative analysis parameters (receptor index: LHL15 and index of blood clearance: HH15). Visual assessment of GSA scintigraphy revealed mildly decreased liver uptake in all of subjects. The mean LHL15 and HH15 were 0.886 and 0.621, graded as mild dysfunction in 2, and mild to moderate dysfunction in 1 subject. In contrast, liver USG showed no remarkable changes of hepatic parenchyme. Tc-GSA scintigraphy was considered as a useful imaging modality in the assessment of the hepatic dysfunction.

Keyword

99mTc-DTPA galactosyl human serum albumin; liver ultrasonography; Amanita subjunquillea poisoning; liver function

MeSH Terms

Asialoglycoprotein Receptor
Heart
Hepatocytes
Humans*
Liver Function Tests
Liver*
Membranes
Poisoning*
Radionuclide Imaging*
Serum Albumin*
Ultrasonography*
Asialoglycoprotein Receptor
Serum Albumin