J Korean Surg Soc.  2010 Jul;79(1):49-57. 10.4174/jkss.2010.79.1.49.

Outcome of Hepatic Resection for Hepatocellular Carcinoma within the Milan Criteria in Child-Pugh Class A Patients

• Kim KH
• Kim JS
• Park JI
• Kim KH
• Choi CS
• Choi YK

• KMID: 1455487
• DOI: http://doi.org/10.4174/jkss.2010.79.1.49

Abstract

PURPOSE
Hepatic resection and liver transplantation are considered a curative treatment for hepatocellular carcinoma (HCC) within the Milan criteria. In this study, we examine the outcome of hepatic resection for HCC within the Milan criteria, and determine the effectiveness of hepatic resection as the primary treatment for HCC within the Milan criteria in Child-Pugh class A.
METHODS
110 patients underwent curative surgical resection for HCC in Child-Pugh class A between August 1991 and June 2008. Fifty-six patients met Milan criteria (Group M) and the remaining 54 did not (Group N).
RESULTS
Overall survival rates at 1, 3, and 5 years were 92.6%, 72.5% and 54.6% versus 70.4%, 43.1%, and 28.7% in Group M and Group N, respectively (P=0.0043). The corresponding disease-free survival rates were 81.5%, 69.7%, and 38.2% versus 46.0%, 32.9%, and 26.9% in Group M and Group N (P=0.0012). HCC recurred in 25 patients in Group M (44.6%) and 35 patients in Group N (64.8%)(P=0.034). Outcomes of hepatic resection in Group M were significantly better compared to Group N.
CONCLUSION
Hepatic resection can achieve a comparable 5-year overall survival & disease-free survival to that reported for liver transplantation. Hepatic resection should be considered as the standard therapy for HCC within the Milan criteria in Child-Pugh class A patients.

Keyword

Hepatic resection; Liver transplantation; Hepatocellular carcinoma; Milan criteria

MeSH Terms

Carcinoma, Hepatocellular
Disease-Free Survival
Humans
Liver Transplantation
Survival Rate

Figure

• 

  Fig. 1 Comparison of overall survival rates between Group M (n=56) and Group N (n=54). Significant difference was observed between two groups (P=0.0034).

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  Fig. 2 Comparison of disease-free survival rate between Group M (n=56) and Group N (n=54). Significant difference was observed between two groups (P=0.0012).

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