J Nutr Health.  2016 Aug;49(4):223-232. 10.4163/jnh.2016.49.4.223.

Validation of G-protein beta-3 subunit gene C825T polymorphism as predictor of obesogenic epidemics in overweight/obese Korean children

• Lee Y
• Park SM
• Lee M

• KMID: 2351350
• DOI: http://doi.org/10.4163/jnh.2016.49.4.223

Abstract

PURPOSE
We investigated the potential interaction between the G-protein beta-3 subunit gene (GNB3) C825T polymorphism, a risk factor for chronic disease in various ethnicities, and obesogenic environments in overweight/obese Korean children.
METHODS
The present study was conducted as a cross-sectional study using measures of anthropometry, blood pressure (BP), and fasting blood samples as well as 3-day food records. Subjects were recruited from seven elementary schools in an urban district in Seoul, South Korea, between 2007 and 2008. A total of 1,260 children aged 8-9 years were recruited in the study, including 633 boys (50.3%) and 627 girls (49.7%).
RESULTS
The allele frequencies of the GNB3 polymorphism were C allele = 49.7% and T allele = 50.3% in subjects. In general, boys with T allele had higher BMI, systolic BP (SBP), and triglycerides, although their energy intake was not significantly different from boys with C allele. In contrast to boys, girls with T allele had lower BMI but higher SBP and energy intake than those with C allele. The girls with T allele had a significantly lower BMI and waist circumference in both the normal weight group and obese group (OB). T allele carriers in both genders had significantly higher TC than C allele carriers in the OB group. At last, girls with T allele in OB appeared to have significantly lower HOMA-IR than those with C allele.
CONCLUSION
Unlike higher risk for negative health outcomes by the GNB3 polymorphism in various ethnicities, GNB3 polymorphism did not influence obesogenic environments in overweight/obese Korean children.

Keyword

children obesity; gender; GNB3 C825T polymorphism; obesogenic

MeSH Terms

Alleles
Anthropometry
Blood Pressure
Child*
Chronic Disease
Cross-Sectional Studies
Energy Intake
Fasting
Female
Gene Frequency
GTP-Binding Proteins*
Humans
Korea
Risk Factors
Seoul
Triglycerides
Waist Circumference
GTP-Binding Proteins
Triglycerides

Figure

• 

  Fig. 1 Experimental research design

• 

  Fig. 2 Anthropometric measurement, lipid profile and insulin resistance-related factors in boys and girls by BMI and GNB3 alleles. Korean childhood obesity classification by BMI percentiles: obesity ≥ 95 percentile, 85 percentile ≤ overweight ≤ 95 percentile, normal weight (NOR) < 85 percentile from the Korean Society of Obesity. The overweight group was included in the obese group (OB). An asterisk (*) indicates the statistical significance with p < 0.05 between the C and T alleles.

• 

  Fig. 3 Characteristics of HDL subfractions and insulin resistance related factors by HDL peak size. Data are represented as the mean ± SD (error bars) adjusted by energy; 1st quartile (n = 16); ≤ 8.80, 2nd quartile (n = 18); 8.81~9.18, 3rd quartile (n = 21); 9.80~10.60, 4th quartile (n = 14); ≥ 10.61. The significance differences were analyzed by ANOVA (p < 0.05) and are expressed as a lowercase letter.

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