Ann Pediatr Endocrinol Metab.  2014 Mar;19(1):8-12. 10.6065/apem.2014.19.1.8.

Iodine and thyroid function

Affiliations
  • 1Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea. chyerim@hanmail.net

Abstract

Severe iodine deficiency causes hypothyroidism that results in impaired somatic growth and motor development in children. Mild and moderate iodine deficiencies cause multifocal autonomous growth of thyroid, which results in thyrotoxicosis. On the other hand, iodine excess is associated with the development of hypothyroidism and thyroid autoimmunity. In areas of iodine deficiency, a sudden increase in iodine intake is associated with transient hyperthyroidism. Recent studies demonstrated that long-term thyroid function of subjects who experienced both iodine deficiency and iodine excess during childhood tended to be abnormal despite optimization of their current iodine intake. Iodine status in the Korean Peninsula is very unique because people in the Republic of Korea have been shown to have predominantly excessive iodine levels, whereas the Democratic People's Republic of Korea is known to be an iodine-deficient area. Further research is warranted to verify the optimal ranges of iodine intake and to clarify the effects of iodine intake on thyroid disorders in the Korean Peninsula.

Keyword

Thyroid; Iodine; Hypothyroidism

MeSH Terms

Autoimmunity
Child
Democratic People's Republic of Korea
Hand
Humans
Hyperthyroidism
Hypothyroidism
Iodine*
Republic of Korea
Thyroid Gland*
Thyrotoxicosis
Iodine

Cited by  2 articles

Excessive Iodine Status among School-Age Children in Korea: A First Report
Young Sik Choi, Soyoung Ock, Sukyoung Kwon, Sang Bong Jung, Kwang-Hyuk Seok, Young Jin Kim, Bu Kyung Kim, Jee-Yeong Jeong
Endocrinol Metab. 2017;32(3):370-374.    doi: 10.3803/EnM.2017.32.3.370.

Association between Iodine Intake, Thyroid Function, and Papillary Thyroid Cancer: A Case-Control Study
Kyungsik Kim, Sun Wook Cho, Young Joo Park, Kyu Eun Lee, Dong-Wook Lee, Sue K. Park
Endocrinol Metab. 2021;36(4):790-799.    doi: 10.3803/EnM.2021.1034.


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