Korean J Fertil Steril.
2001 Sep;28(3):209-214.
A Study of Factor XII Deficiency in Recurrent Spontaneous Abortion
- Affiliations
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- 1Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University, Pocheon, Korea.
- 2Department of Genetics, College of Medicine, Pocheon CHA University, Pocheon, Korea.
- 3Department of Clinical Pathology, College of Medicine, Pocheon CHA University, Pocheon, Korea.
- 4Department of Internal Medicine, College of Medicine, Pocheon CHA University, Pocheon, Korea.
Abstract
OBJECTIVE
To evaluate factor XII deficiency in patients with recurrent spontaneous abortion and its relation to aPTT. MATERIAL AND METHOD: Factor XII was analyzed by clotting method.
RESULTS
Of 70 patients with recurrent spontaneous abortion, there were 35 cases of factor XII deficiency. Among them, there were only 3 cases of prolonged aPTT.
CONCLUSIONS
It is still unclear whether factor XII deficiency is related to recurrent spontaneous abortion. Molecular approaches should be used to understand further the causal relationship. But based on this result, in the workup of patients with recurrent spontaneous abortion, factor XII should be included. aPTT is not likely to represent the abnormality of factor XII.
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