J Korean Pediatr Soc.
2003 Oct;46(10):1029-1031.
A Case of Hemophagocytic Lymphohistiocytosis in a Child with Systemic Lupus Erythematosus
- Affiliations
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- 1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. jintackk@catholic.ac.kr
Abstract
- Hemophagocytic lymphohistiocytosis is a reactive disorder characterized by a generalized non-malignant histiocytic proliferation with prominent hemophagocytosis by stimulated histiocytes in the bone marrow and reticuloendothelial systems resulting in pancytopenia and liver dysfunction. Several diseases including infection, malignancy and autoimmune disease are known to be causative disorders. This case demonstrated histiocytic hemophagocytosis in the bone marrow, resulting in pancytopenia during treatment of systemic lupus erythematosus and did not show any underlying disease.
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