Allergy Asthma Respir Dis.  2016 Nov;4(6):429-435. 10.4168/aard.2016.4.6.429.

Prediction of the severity and length of hospital stay in infants with acute bronchiolitis using the severity score

Affiliations
  • 1Department of Pediatrics, Korea University College of Medicine, Seoul, Korea. wonny508@korea.ac.kr
  • 2Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

PURPOSE
This study aimed to evaluate the clinical factors that could influence the length of hospital stay (LHS) of infants with acute bronchiolitis using the bronchiolitis severity score (BSS).
METHODS
The medical records of 105 infants aged 0-12 months with acute bronchiolitis who were admitted to a tertiary hospital between December 2014 and May 2015 were reviewed. The BSS was composed 5 factors, namely general condition, wheezing, chest retraction, respiration rate, and peripheral oxygen saturation, which were evaluated at admission. In addition, the age of the infants, LHS, body weight, birth history, familial history, laboratory test result, chest X-ray, and treatment modalities were reviewed. Subjects were classified into 3 groups according to their BSS, and logistic regression analysis was used to identify the association of the BSS with longer LHS.
RESULTS
Among subjects, 62 were studied. Their mean LHS and age were 5.5±2.0 days and 3.9±2.7 months, respectively. Twelve infants were classified as mild (20.3%), 43 as moderate (68.8%), and 7 as severe (10.9%). Venous blood gas pH value and white blood cell count were the best predictors of disease severity. The LHS was associated with the BSS, age, body weight and pCO2 by venous blood gas analysis (P<0.05).
CONCLUSION
The LHS was associated with the BSS, age, body weight, and pCOâ‚‚ by venous blood gas analysis at admission. The BSS could be a useful tool to predict disease severity and decide treatment strategies for infants with acute bronchiolitis who have no known risk factors.

Keyword

Bronchiolitis; Hospitalization; Infant; Hospital stay; Severity

MeSH Terms

Blood Gas Analysis
Body Weight
Bronchiolitis*
Hospitalization
Humans
Hydrogen-Ion Concentration
Infant*
Length of Stay*
Leukocyte Count
Logistic Models
Medical Records
Oxygen
Reproductive History
Respiratory Rate
Respiratory Sounds
Risk Factors
Tertiary Care Centers
Thorax
Oxygen

Figure

  • Fig. 1 Percentage of oxygen therapy and use of systemic corticosteroid in each groups by bronchial severity score (BSS). BSS: mild, 0–5; moderate, 6–10; severe, >10.


Cited by  2 articles

Clinical characteristics and genetic variation in respiratory syncytial virus isolated from infants hospitalized due to acute bronchiolitis in Korea during winter season 2016–2017
Dong Keon Yon, Chae-Yeon Min, Eun Kyo Ha, Hye Mi Jee, Young-Ho Jung, Kyung Suk Lee, Youn Ho Sheen, Man Yong Han
Allergy Asthma Respir Dis. 2018;6(2):110-115.    doi: 10.4168/aard.2018.6.2.110.

Bronchiolitis severity according to the infected viruses
Su Jin Lee, Sang Kyu Park, Ji Hyun Kim, Sung Min Cho
Allergy Asthma Respir Dis. 2018;6(1):47-53.    doi: 10.4168/aard.2018.6.1.47.


Reference

1. American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis. Pediatrics. 2006; 118:1774–1793.
2. Coates BM, Camarda LE, Goodman DM. Wheezing, bronchiolitis, and bronchitis. In : Kliegman RM, Stanton BF, St. Geme JW, Schor NF, Behrman RE, editors. Nelson textbook of pediatrics. 20th ed. Philadelphia: Elsevier/Saunders;2014. p. 2044–2050.
3. Mansbach JM, Emond JA, Camargo CA Jr. Bronchiolitis in US emergency departments 1992 to 2000: epidemiology and practice variation. Pediatr Emerg Care. 2005; 21:242–247.
4. Hasegawa K, Tsugawa Y, Brown DF, Mansbach JM, Camargo CA Jr. Temporal trends in emergency department visits for bronchiolitis in the United States, 2006 to 2010. Pediatr Infect Dis J. 2014; 33:11–18.
Article
5. Roh EJ, Won YK, Lee MH, Chung EH. Clinical characteristics of patients with acute bronchiolitis who visited 146 Emergency Department in Korea in 2012. Allergy Asthma Respir Dis. 2015; 3:334–340.
Article
6. Gouyon JB, Rozé JC, Guillermet-Fromentin C, Glorieux I, Adamon L, DI Maio M, et al. Hospitalizations for respiratory syncytial virus bronchiolitis in preterm infants at <33 weeks gestation without bronchopulmonary dysplasia: the CASTOR study. Epidemiol Infect. 2013; 141:816–826.
Article
7. Feltes TF, Cabalka AK, Meissner HC, Piazza FM, Carlin DA, Top FH Jr, et al. Palivizumab prophylaxis reduces hospitalization due to respiratory syncytial virus in young children with hemodynamically significant congenital heart disease. J Pediatr. 2003; 143:532–540.
Article
8. Wang EE, Milner RA, Navas L, Maj H. Observer agreement for respiratory signs and oximetry in infants hospitalized with lower respiratory infections. Am Rev Respir Dis. 1992; 145:106–109.
Article
9. Liu LL, Gallaher MM, Davis RL, Rutter CM, Lewis TC, Marcuse EK. Use of a respiratory clinical score among different providers. Pediatr Pulmonol. 2004; 37:243–248.
Article
10. Destino L, Weisgerber MC, Soung P, Bakalarski D, Yan K, Rehborg R, et al. Validity of respiratory scores in bronchiolitis. Hosp Pediatr. 2012; 2:202–209.
Article
11. Lowell D, Lister G, Von Koss H, McCarthy P. Wheezing in infants: the response to epinephrine. Pediatrics. 1987; 79:939–945.
Article
12. Corneli HM, Zorc JJ, Holubkov R, Bregstein JS, Brown KM, Mahajan P, et al. Bronchiolitis: clinical characteristics associated with hospitalization and length of stay. Pediatr Emerg Care. 2012; 28:99–103.
13. Voets S, van Berlaer G, Hachimi-Idrissi S. Clinical predictors of the severity of bronchiolitis. Eur J Emerg Med. 2006; 13:134–138.
Article
14. Alansari K, Sakran M, Davidson BL, Ibrahim K, Alrefai M, Zakaria I. Oral dexamethasone for bronchiolitis: a randomized trial. Pediatrics. 2013; 132:e810–e816.
Article
15. Kim KH, Hwang J, Song JH, Lee YS, Kwon JW, Suh DI, et al. Association between the clinical index and disease severity in infants with acute bronchiolitis. Allergy Asthma Respir Dis. 2013; 1:377–382.
Article
16. Marlais M, Evans J, Abrahamson E. Clinical predictors of admission in infants with acute bronchiolitis. Arch Dis Child. 2011; 96:648–652.
Article
17. Mansbach JM, Clark S, Christopher NC, LoVecchio F, Kunz S, Acholonu U, et al. Prospective multicenter study of bronchiolitis: predicting safe discharges from the emergency department. Pediatrics. 2008; 121:680–688.
Article
18. Lind I, Gill JH, Calabretta N, Polizzoto M. Clinical inquiries. What are hospital admission criteria for infants with bronchiolitis? J Fam Pract. 2006; 55:67–69.
19. Cha MA, Woo YR, Kim HJ, Kim MS, Ahn YH. Factors associated with obesity of acute bronchiolitis in infants: association of obesity with disease severity. Allergy Asthma Respir Dis. 2015; 3:281–287.
Article
20. Katona PG, Egbert JR. Heart rate and respiratory rate differences between preterm and full-term infants during quiet sleep: possible implications for sudden infant death syndrome. Pediatrics. 1978; 62:91–95.
Article
21. Walsh P, Rothenberg SJ, O'Doherty S, Hoey H, Healy R. A validated clinical model to predict the need for admission and length of stay in children with acute bronchiolitis. Eur J Emerg Med. 2004; 11:265–272.
Article
22. Corrard F, de La Rocque F, Martin E, Wollner C, Elbez A, Koskas M, et al. Food intake during the previous 24 h as a percentage of usual intake: a marker of hypoxia in infants with bronchiolitis: an observational, prospective, multicenter study. BMC Pediatr. 2013; 13:6.
Article
23. Lemke M, Hartert TV, Gebretsadik T, Carroll KN. Relationship of secondhand smoke and infant lower respiratory tract infection severity by familial atopy status. Ann Allergy Asthma Immunol. 2013; 110:433–437.
Article
24. Mahabee-Gittens M. Smoking in parents of children with asthma and bronchiolitis in a pediatric emergency department. Pediatr Emerg Care. 2002; 18:4–7.
Article
25. Bryan DL, Hart PH, Forsyth KD, Gibson RA. Immunomodulatory constituents of human milk change in response to infant bronchiolitis. Pediatr Allergy Immunol. 2007; 18:495–502.
Article
26. Carroll KN, Gebretsadik T, Griffin MR, Dupont WD, Mitchel EF, Wu P, et al. Maternal asthma and maternal smoking are associated with increased risk of bronchiolitis during infancy. Pediatrics. 2007; 119:1104–1112.
Article
27. Lanari M, Prinelli F, Adorni F, Di Santo S, Vandini S, Silvestri M, et al. Risk factors for bronchiolitis hospitalization during the first year of life in a multicenter Italian birth cohort. Ital J Pediatr. 2015; 41:40.
Article
28. Pelletier AJ, Mansbach JM, Camargo CA Jr. Direct medical costs of bronchiolitis hospitalizations in the United States. Pediatrics. 2006; 118:2418–2423.
Article
29. Kini NM, Robbins JM, Kirschbaum MS, Frisbee SJ, Kotagal UR. Child Health Accountability Initiative. Inpatient care for uncomplicated bronchiolitis: comparison with Milliman and Robertson guidelines. Arch Pediatr Adolesc Med. 2001; 155:1323–1327.
30. Leader S, Kohlhase K. Recent trends in severe respiratory syncytial virus (RSV) among US infants, 1997 to 2000. J Pediatr. 2003; 143:5 Suppl. S127–S132.
Article
31. Castro-Rodriguez JA, Rodriguez-Martinez CE, Sossa-Briceño MP. Principal findings of systematic reviews for the management of acute bronchiolitis in children. Paediatr Respir Rev. 2015; 16:267–275.
Article
32. Turner T, Wilkinson F, Harris C, Mazza D. Health for Kids Guideline Development Group. Evidence based guideline for the management of bronchiolitis. Aust Fam Physician. 2008; 37(6 Spec No):6–13.
33. Ralston SL, Lieberthal AS, Meissner HC, Alverson BK, Baley JE, Gadomski AM, et al. Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics. 2014; 134:e1474–e1502.
Article
34. Baumer JH. SIGN guideline on bronchiolitis in infants. Arch Dis Child Educ Pract Ed. 2007; 92:ep149–ep151.
Article
35. Kim JS, In DK, Sun YH, Hong HJ, Cho KH, Son DW, et al. Current Management of Acute Bronchiolitis in Incheon. Pediatr Allergy Respir Dis. 2006; 16:150–161.
36. McCulloh RJ, Smitherman SE, Koehn KL, Alverson BK. Assessing the impact of national guidelines on the management of children hospitalized for acute bronchiolitis. Pediatr Pulmonol. 2014; 49:688–694.
Article
Full Text Links
  • AARD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr