Allergy Asthma Respir Dis.  2016 Jul;4(4):276-283. 10.4168/aard.2016.4.4.276.

The change in food allergy prevalence of elementary school children in Seoul since the last 20 years and the risk factor analysis

Affiliations
  • 1Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sjhong@amc.seoul.kr
  • 2Department of Pediatrics, Hallym University Sacred Heart Hospital, Anyang, Korea.
  • 3Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan, Korea.
  • 4Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
  • 5Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
  • 6Division of Allergy and Respiratory Diseases, National Institute of Health, Korea Center for Disease Control and Prevention, Cheongju, Korea.

Abstract

PURPOSE
There are many reports that the prevalence of food allergy (FA) is globally increasing. We investigated the change in FA prevalence since the last 20 years in elementary school children, in Seoul, Korea.
METHODS
A modified International Study of Asthma and Allergies in Childhood questionnaire survey was done to elementary school children in Seoul, Korea in 1995, 2000, 2005, 2008, and 2012. The numbers of subjects included in the analysis were 7,963, 7,971, 7,131, 3,975, and 3,307, respectively. Blood and skin prick tests were done in 2008 and 2012.
RESULTS
The prevalence rates of FA diagnosis ever were 4.6% (95% confidence interval [CI], 4.1-5.1), 5.2% (95% CI, 4.7-5.7), 6.4% (95% CI, 5.9-7.0), 5.5% (95% CI, 4.8-6.3), and 6.6% (95% CI, 5.8-7.6) in 1995, 2000, 2005, 2008, and 2012, respectively (P-value for trend <0.001). Asthma (adjusted odds ratio [aOR], 2.209; 95% CI, 1.589-3.072), allergic rhinitis (aOR, 1.874; 95% CI, 1.473-2.384), and atopic dermatitis (aOR, 4.288; 95% CI, 3.340-5.506) were associated with FA diagnosis. Parental allergic disease history (aOR, 2.191; 95% CI, 1.666-2.881), antibiotics use in infancy (aOR, 1.484; 95% CI, 1.170-1.883), and house mold exposure in infancy (aOR, 1.540; 95% CI, 1.172-2.024) were risk factors for FA diagnosis. Sensitization to inhalant allergens (aOR, 1.867; 95% CI, 1.091-3.194) and increased serum total IgE (aOR, 2.014; 95% CI, 1.081-3.752) were associated with FA diagnosis.
CONCLUSION
The prevalence of FA diagnosis is likely to be increasing since the last 20 years in Seoul. Antibiotics use in infancy and house mold exposure in infancy were risk factors for FA diagnosis.

Keyword

Food allergy; Prevalence; Child; Risk factor

MeSH Terms

Allergens
Anti-Bacterial Agents
Asthma
Child*
Dermatitis, Atopic
Diagnosis
Food Hypersensitivity*
Fungi
Humans
Hypersensitivity
Immunoglobulin E
Korea
Odds Ratio
Parents
Prevalence*
Rhinitis, Allergic
Risk Factors*
Seoul*
Skin
Allergens
Anti-Bacterial Agents
Immunoglobulin E

Figure

  • Fig. 1 The change of food allergy prevalence by year. FA, food allergy.


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