Nutr Res Pract.  2013 Feb;7(1):34-42.

Effect of the magnetized water supplementation on blood glucose, lymphocyte DNA damage, antioxidant status, and lipid profiles in STZ-induced rats

• Lee HJ
• Kang MH

Abstract

This study investigated the effects of magnetized water supplementation on blood glucose, DNA damage, antioxidant status, and lipid profiles in streptozotocin (STZ)-induced diabetic rats. There were three groups of 4-week-old male Sprague-Dawley rats used in the study: control group (normal control group without diabetes); diabetes group (STZ-induced diabetes control); and magnetized water group (magnetized water supplemented after the induction of diabetes using STZ). Before initiating the study, diabetes was confirmed by measuring fasting blood glucose (FBS > 200 dl), and the magnetized water group received magnetized water for 8 weeks instead of general water. After 8 weeks, rats were sacrificed to measure the fasting blood glucose, insulin concentration, glycated hemoglobin level, degree of DNA damage, antioxidant status, and lipid profiles. From the fourth week of magnetized water supplementation, blood glucose was decreased in the magnetized water group compared to the diabetes group, and such effect continued to the 8th week. The glycated hemoglobin content in the blood was increased in the diabetes group compared to the control group, but decreased significantly in the magnetized water group. However, decreased plasma insulin level due to induced diabetes was not increased by magnetized water supplementation. Increased blood and liver DNA damages in diabetes rats did significantly decrease after the administration of magnetized water. In addition, antioxidant enzyme activities and plasma lipid profiles were not different among the three groups. In conclusion, the supplementation of magnetized water not only decreased the blood glucose and glycated hemoglobin levels but also reduced blood and liver DNA damages in STZ-induced diabetic rats. From the above results, it is suggested that the long-term intake of the magnetized water over 8 weeks may be beneficial in both prevention and treatment of complications in diabetic patients.

Keyword

Magnetized water; blood glucose; DNA damage; lipid profile; STZ-induced rat

MeSH Terms

Animals
Blood Glucose
DNA
DNA Damage
Fasting
Hemoglobins
Humans
Insulin
Liver
Lymphocytes
Magnets
Male
Plasma
Rats
Rats, Sprague-Dawley
Streptozocin
Water
Blood Glucose
DNA
Hemoglobins
Insulin
Streptozocin
Water

Figure

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  Fig. 1 Effect of magnetized water on blood glucose levels in STZ-induced diabetic rats. Mean ± SD. C, Control (n = 8); DC, Diabetes Control (n = 6); DMW, Diabetes + Magnetized Water (n = 5). Points with different letters between groups are significantly different at P < 0.05 after Duncan's multiple range test.

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  Fig. 2 Effect of magnetized water on intra-peritoneal glucose tolerance in STZ-induced diabetic rats. Mean ± SD. C, Control (n = 8); DC, Diabetes Control (n = 6); DMW, Diabetes + Magnetized Water (n = 5). Points with different letters within each group are significantly different at P < 0.05 after Duncan's multiple range test.

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  Fig. 3 Effect of magnetized water on plasma insulin levels in STZ-induced diabetic rats. Mean ± SD. C, Control (n = 8); DC, Diabetes Control (n = 6); DMW, Diabetes + Magnetized Water (n = 5). Bars with different letters are significantly different at P < 0.05 after Duncan's multiple range test

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  Fig. 4 Effect of magnetized water on blood HbA1c levels in STZ-induced diabetic rats. Mean ± SD. C, Control (n = 8); DC, Diabetes Control (n = 6); DMW, Diabetes + Magnetized Water (n = 5). Bars with different letters are significantly different at P < 0.05 after Duncan's multiple range test.

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  Fig. 5 Protective effect of magnetized water on blood DNA damages in STZ-induced diabetic rats. Mean ± SD. C, Control (n = 8); DC, Diabetes Control (n = 6); DMW, Diabetes + Magnetized Water (n = 5). Bars with different letters are significantly different at P < 0.05 after Duncan's multiple range test.

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  Fig. 6 Protective effect of magnetized water on liver DNA damages in STZ-induced diabetic rats. Mean ± SD. C, Control (n = 8), DC, Diabetes Control (n = 6); DMW, Diabetes + Magnetized Water (n = 5). Bars with different letters are significantly different at P < 0.05 after Duncan's multiple range test.

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