Korean J Nutr.
2007 Oct;40(7):630-638.
The Effect of L-Carnitine and Isoflavone Supplementation on Weight Reduction and Visceral Fat Accumulation in Overweight Women
- Affiliations
-
- 1Interdisciplinary Program: Science for Aging, Yonsei University, Seoul 120-749, Korea.
- 2National Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Yonsei University, Seoul 120-749, Korea.
- 3Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul 120-749, Korea.
- 4Health Products Research Team, Food Research Institute, R&D Center, Amore Pacific Co., Yongin 446-729, Korea.
Abstract
- This study was performed to examine the combined effects of L-carnitine and isoflavone supplementation on weight reduction and body fat distribution in overweight women. Overweight/obese women (body mass index > 23 kg/m2) who were not diagnosed any type of diseases were included in this study and sixty subjects (41.1 +/- 1.5 years, 25.9 +/- 0.3 kg/m2) were randomly assigned to a placebo (n = 30) or a supplement group (n = 30, L-carnitine 300 mg + isoflavone 40 mg/day). We measured anthropometric parameters, abdominal fat distribution by computerizd tomography and blood components before and after the 12 week intervention period. After the 12 weeks of supplementation, subjects in L-carnitine and isoflavone supplement group showed a significant reduction of body weight (p < 0.001), body fat % (p < 0.05), and waist to hip ratio (p < 0.01) whereas placebo group did not show any changes. In a CT-scanned results, total fat area at L4 level was significantly reduced by 8.1% (p < 0.01) with the reduction of visceral fat area (-11.1%, p < 0.001) and subcutaneous fat area (-7.0%, p < 0.05) in the supplement group. The supplementation of L-carnitine and isoflavone showed the significant improvement of HDL-C (p < 0.01) and apoB (p < 0.05) concentrations, however, change values in those markers were not significant compared with those of the placebo group. In addition, a significant increase of adiponectin level (p < 0.001) was observed in the supplement group after the intervention. The result of present study demonstrated that supplementation of 300 mg L-carnitine and 40 mg isoflavone per day for 12 weeks can give beneficial effects on weight reduction and visceral fat accumulation. These potential antiobesity supplement can produce more favorable effects when combined with lifestyle modification.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- The Effect of L-Carnitine and Isoflavone Supplementation on Weight Reduction and Visceral Fat Accumulation in Overweight Women
- The Effect of a Potential Antiobesity-Supplement on Weight Loss and Visceral Fat Accumulation in Overweight Women
- The Effect of Green Coffee Bean Extract Supplementation on Body Fat Reduction in Overweight/Obese Women
- Effect of Treadmill Exercise Training and Dietary Intake of Garcinia Cambogia Extract, Soypeptide and L-Carnitine Mixture on Body Weight Reduction in Rats Fed High-Fat Diet
- Visceral fat and body weight are reduced in overweight adults by the supplementation of Doenjang, a fermented soybean paste
