Korean J Pediatr Gastroenterol Nutr.  2005 Mar;8(1):1-11.

Helicobacter pylori Infection in Children with Recurrent Abdominal Pain

Affiliations
  • 1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. jkseo@plaza.snu.ac.kr

Abstract

PURPOSE: The aim of this study was to evaluate the relationship between H. pylori infection and recurrent abdominal pain (RAP) in children and to evaluate the effects of eradication therapy on RAP.
METHODS
From January 1998 to January 2005, 166 children with RAP (61 male, 105 female) aged 10.0+/-3.3 years were included. Upper gastrointestinal endoscopies were performed for all the patients. All H. pylori infected children (n=70) received the eradication therapy and were divided into two groups: Group Ia (n=52); eradicated, Group Ib (n=18); non-eradicated. H. pylori-negative children (n=96) were divided into three groups according to the medication: Group IIa (n=67); no medication, Group IIb (n=13); acid-suppressant, Group IIc (n=16); both acid-suppressant and antibiotics. Questionnaire for symptoms were asked at the first, 6th, 12th, 24th, and 36th months following the treatment (grade 0; completely resolved, grade 1; definitely improved, but there are occasional episodes of mild abdominal pain, grade 2; no change in the frequency and intensity of abdominal pain).
RESULTS
In about 90% of H. pylori positive children, RAP improved in the both H. pylori-eradicated and non-eradicated children in a follow-up survey. In about 75% of H. pylori-negative children, RAP also improved among in the three groups of patients regardless of medication.
CONCLUSION
These results suggest that there was no correlations between improvement of RAP and eradication of H. pylori, and between improvement of RAP and medication. Consequently the reassurance that the children with RAP have no serious organic cause was important to improvement of RAP.

Keyword

Recurrent abdominal pain; Helicobacter pylori; Eradication therapy; Children

MeSH Terms

Abdominal Pain*
Anti-Bacterial Agents
Child*
Endoscopy, Gastrointestinal
Follow-Up Studies
Helicobacter pylori*
Helicobacter*
Humans
Male
Surveys and Questionnaires
Anti-Bacterial Agents
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