J Korean Med Assoc.  2018 May;61(5):304-308. 10.5124/jkma.2018.61.5.304.

National dementia research and development project

Affiliations
  • 1Department of Neurology, Asan Medical Center, University Ulsan College of Medicine, Seoul, Korea. jhlee@amc.seoul.kr

Abstract

The Ministry of Science and ICT and the Ministry of Health and Welfare of the Republic of Korea have organized the first National Committee for Dementia Research, to which all domestic experts in the field have been invited as they endeavor to achieve "˜national dementia liability', which is one of the core national agenda items of the current Korean government. To make this initiative sustainable and bring dementia under control, we should not focus only on providing care and economic support to the family of patients with dementia. Instead, a large-scale, long-term research and development (R&D) strategy for dementia prevention, diagnosis, and therapy is warranted. This R&D project comprises several parts: 1) elucidation of the etiology and prevention of dementia, 2) innovative diagnostics for dementia, 3) tailored therapies for dementia, and 4) tangible and effective care for dementia. Given the fact that dementia is a very heterogeneous condition involving multiple pathogenic factors and typically having a chronic disease course, comprehensive and integrated approaches across various disciplines should be explored for primary, secondary, and tertiary prevention of this disease. With the success of this R&D project, the national dementia liability system will gain momentum and come into its own. Integrated efforts in terms of both policyrelated and scientific initiatives would allow us to take a step closer to realizing our shared goal of living in a world of dementia carefree.

Keyword

Alzheimer disease; Research; Prevention & control; Diagnosis

MeSH Terms

Alzheimer Disease
Chronic Disease
Dementia*
Diagnosis
Humans
Republic of Korea
Tertiary Prevention

Cited by  1 articles

Dementia Research Using Healthcare Big Data
Hun-Sung Kim, Dai-Jin Kim
Dement Neurocogn Disord. 2019;18(3):73-76.    doi: 10.12779/dnd.2019.18.3.73.


Reference

1. Kim YJ, Han JW, So YS, Seo JY, Kim KY, Kim KW. Prevalence and trends of dementia in Korea: a systematic review and meta-analysis. J Korean Med Sci. 2014; 29:903–912.
Article
2. Jevtic S, Sengar AS, Salter MW, McLaurin J. The role of the immune system in Alzheimer disease: etiology and treatment. Ageing Res Rev. 2017; 40:84–94.
Article
3. Quigley EM. Microbiota-brain-gut axis and neurodegenera-tive diseases. Curr Neurol Neurosci Rep. 2017; 17:94.
Article
4. Arnold SE, Arvanitakis Z, Macauley-Rambach SL, Koenig AM, Wang HY, Ahima RS, Craft S, Gandy S, Buettner C, Stoeckel LE, Holtzman DM, Nathan DM. Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums. Nat Rev Neurol. 2018; 14:168–181.
Article
5. Lassen PS, Thygesen C, Larsen MR, Kempf SJ. Understanding Alzheimer's disease by global quantification of protein phosphorylation and sialylated N-linked glycosylation pro-files: a chance for new biomarkers in neuroproteomics? J Proteomics. 2017; 161:11–25.
Article
6. Mesulam MM. A plasticity-based theory of the pathogenesis of Alzheimer's disease. Ann N Y Acad Sci. 2000; 924:42–52.
Article
7. Ngandu T, Lehtisalo J, Solomon A, Levalahti E, Ahtiluoto S, Antikainen R, Backman L, Hanninen T, Jula A, Laatikainen T, Lindstrom J, Mangialasche F, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015; 385:2255–2263.
Article
8. Moll van Charante EP, Richard E, Eurelings LS, van Dalen JW, Ligthart SA, van Bussel EF, Hoevenaar-Blom MP, Vermeulen M, van Gool WA. Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial. Lancet. 2016; 388:797–805.
Article
9. Andrieu S, Guyonnet S, Coley N, Cantet C, Bonnefoy M, Bordes S, Bories L, Cufi MN, Dantoine T, Dartigues JF, Desclaux F, Gabelle A, Gasnier Y, Pesce A, Sudres K, Touchon J, Robert P, Rouaud O, Legrand P, Payoux P, Caubere JP, Weiner M, Carrie I, Ousset PJ, Vellas B. MAPT Study Group. Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory compla-ints (MAPT): a randomised, placebo-controlled trial. Lancet Neurol. 2017; 16:377–389.
10. Shi L, Baird AL, Westwood S, Hye A, Dobson R, Thambisetty M, Lovestone S. A decade of blood biomarkers for Alzheimer's disease research: an evolving field, improving study designs, and the challenge of replication. J Alzheimers Dis. 2018; 62:1181–1198.
Article
Full Text Links
  • JKMA
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr