Korean J Phys Anthropol.
2004 Dec;17(4):313-320.
BF-7 Improved Memory Function and Protected Neuron from Oxidative Stress
- Affiliations
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- 1Department of Anatomy, College of Medicine, Chung Ang University, Korea. whitefox@cau.ac.kr
- 2Department of Physiology, College of Medicine, Chung Ang University, Korea.
- 3Department of Neuropsychiatry, College of Medicine, Chung Ang University, Korea.
- 4Department of Nursing Science, College of Medicine, Chung Ang University, Korea.
- 5Department of Opthalmology, College of Medicine, Chung Ang University, Korea.
- 6Department of Neurosurgery, College of Medicine, Seoul National University, Korea.
- 7Department of Cardiovascular Surgery, College of Medicine, Seoul National University, Korea.
- 8Department of Sericulture and Entomology, National Institute of Agriculture Science and Technology, Korea.
Abstract
- Endogenously or exogenously generated oxidative stress impair organs, especially brain. Also, the oxidative stress appears to be a negative factor on normal brain function, like memory and cognition. Our result showed that BF-7, extracted from Bombyx mori, effectively diminished oxidative stress, leading to the protection of neuron from reactive oxygen species donated by FeSO4 . Clinical experiments showed that BF-7 significantly improved memory and cognitive functions of normal adults in a dose-dependent manner. Thus, our results suggest that BF-7 play a role in the improvement of brain functions by removing oxidative stress, and provide therapeutic potential role of BF-7 to protect nervous system from oxidative damage.
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