J Korean Epilepsy Soc.
2006 Dec;10(2):146-152.
Cognitive Profiles of Lamotrigine in Epilepsy Patients : A Comparative Study with Valproate
- Affiliations
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- 1Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Korea. sppark@mail.knu.ac.kr
- 2Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea.
Abstract
- PURPOSE
To identify cognitive effects of lamotrigine (LTG) compared with valproate (VPA) in epilepsy patients after 1 year of treatment.
METHODS
Cognitive tests and subjective complaints of 22 patients with LTG monotherapy (50-200 mg/day) were retrospectively compared with those of 22 patients with VPA monotherapy (500-1300 mg/day) at 1 year of medication.
RESULTS
LTG group did not show any significant difference in the performance of cognitive tests compared with VPA group. The incidence of cognitive complaints between two drugs were also not different. Both groups showed a better performance of list learning and Trail Making Test type A after antiepileptic drug medication.
CONCLUSION
The impact of LTG and VPA monotherapy on cognitive functioning is similar. Both drugs may not be harmful or rather slightly beneficial for cognitive functions.
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