J Korean Soc Spine Surg.  2008 Jun;15(2):102-105. 10.4184/jkss.2008.15.2.102.

Multidrug-resistant Tuberculosis Spondylitis: A Case Report

• Ki SC
• Kim KS
• Kim YH
• Choi YS

• KMID: 2097839
• DOI: http://doi.org/10.4184/jkss.2008.15.2.102

Abstract

Multidrug-resistant tuberculosis, resistant to at least isoniazid and rifampicin, continues to present a serious challenge to human health. However, there are no reports addressing multidrug-resistant tuberculous spondylitis in Korea. We report a case of multidrug-resistant tuberculous spondylitis at L2-L3 in a 30-year-old woman.

Keyword

Tuberculosis spondylitis; Multidrug resistance

MeSH Terms

Adult
Drug Resistance, Multiple
Humans
Isoniazid
Korea
Rifampin
Spondylitis
Tuberculosis
Tuberculosis, Multidrug-Resistant
Isoniazid
Rifampin

Figure

• 

  Fig. 1. Preoperative radiographs and MR Imaging. (A) Radiographs show destruction of vertebral body and kyphotic deformity (Sagittal index: 40 degrees) at L2-3. (B) Sagittal T1 and T2-weighted imaging of L2-3 demonstrate destruction of vertebral bodies and compression of dural sacs. Axial T2-weighted images show the abscess formation at psoas muscle, right.

• 

  Fig. 2. Histologic finding shows caseous necrosis with chronic granulated inflammation (H-E×100).

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  Fig. 3. Radiographs and MR Imaging at 26months after the operation. (A) Radiographs show collapse of grafted bone, destruction of vertebral bodies and kyphotic deformity at L2-4. (B) Sagittal T1 and T2-weighted imaging of L2-4 demonstrate destruction of vertebral bodies and severe compression of dural sacs. Axial T2-weighted images show the large abscess formation at psoas muscle and fistula formation, right.

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  Fig. 4. Tuberculosis drug sensitivity test result in drug-resistant for Isoniazid, Rifampicin and Streptomycin.

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  Fig. 5. Radiographs at 18months after 2nd operation show well bony fusion at L2-3-4.

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