Pediatr Allergy Respir Dis.  2011 Jun;21(2):74-77.

Epidemiologic Study and Risk Factors of Atopic Dermatitis

• Park YM

Abstract

Atopic dermatitis (AD) is one of the most common chronic childhood skin diseases affecting up to 30% of children in the Korea. The point prevalence of AD has increased based on validated questionnaires in the most recent update of the International Study of Asthma and Allergies in Childhood. The evaluation of risk factors of AD is very important to develop the therapeutic strategies of AD. Many risk factors were studied to evaluate the relationship with the prevalence of AD. However, the results were quite different depending on methods of study, study population, and country. The further objective and well designed prospective epidemiologic studies are required to confirm these outcomes because the environmental and risk factors may be different among the countries according to their living cultures.

Keyword

Atopic dermatitis; Risk factors; Epidemiologic studies

MeSH Terms

Asthma
Child
Dermatitis, Atopic
Epidemiologic Studies
Humans
Hypersensitivity
Korea
Prevalence
Surveys and Questionnaires
Risk Factors
Skin Diseases

Reference

References

1. Oh JW, Pyun BY, Choung JT, Ahn KM, Kim CH, Song SW, et al. Epidemiological change of atopic dermatitis and food allergy in school-aged children in Korea between 1995 and 2000. J Korean Med Sci. 2004; 19:716–2.

2. Schultz Larsen F. Genetic epidemiology of atopic dermatitis. Williams HC, editor. Atopic Dermatitis: The Epidemiology, Causes and Prevention of Atopic Eczema. Cambridge: Cambridge University Press;2000. p. 113–24.

3. Ziyab AH, Raza A, Karmaus W, Tongue N, Zhang H, Matthews S, et al. Trends in eczema in the first 18 years of life: results from the Isle of Wight 1989 birth cohort study. Clin Exp Allergy. 2010; 40:1776–84.

4. Schultz Larsen F, Hanifin JM. Secular change in the occurrence of atopic dermatitis. Acta Derm Venereol Suppl (Stockh). 1992; 176:7–12.

5. Hwang CY, Chen YJ, Lin MW, Chen TJ, Chu SY, Chen CC, et al. Prevalence of atopic dermatitis, allergic rhinitis and asthma in Taiwan: a national study 2000 to 2007. Acta Derm Venereol. 2010; 90:589–94.

6. Yoo S, Kim HB, Lee SY, Kim BS, Kim JH, Yu JH, et al. Association between obesity and the prevalence of allergic diseases, atopy, and bronchial hyperresponsiveness in Korean adolescents. Int Arch Allergy Immunol. 2011; 154:42–8.

7. van de Ven MO, van den Eijnden RJ, Engels RC. Atopic diseases and related risk factors among Dutch adolescents. Eur J Public Health. 2006; 16:549–58.

8. Kilpelainen M, Terho EO, Helenius H, Koskenvuo M. Body mass index and physical activity in relation to asthma and atopic diseases in young adults. Respir Med. 2006; 100:1518–25.

9. von Mutius E, Weiland SK, Fritzsch C, Duhme H, Keil U. Increasing prevalence of hay fever and atopy among children in Leipzig, East Germany. Lancet. 1998; 351:862–6.

10. Song S, Lee K, Lee YM, Lee JH, Lee SI, Yu SD, et al. Acute health effects of urban fine and ultrafine particles on children with atopic dermatitis. Environ Res. 2011; 111:394–9.

11. Langan SM, Flohr C, Williams HC. The role of furry pets in eczema: a systematic review. Arch Dermatol. 2007; 143:1570–7.

12. Epstein TG, Bernstein DI, Levin L, Khurana Hershey GK, Ryan PH, Reponen T, et al. Opposing effects of cat and dog ownership and allergic sensitization on eczema in an atopic birth cohort. J Pediatr. 2011; 158:265–71.

13. Biagini Myers JM, Wang N, LeMasters GK, Bernstein DI, Epstein TG, Lindsey MA, et al. Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort. J Invest Dermatol. 2010; 130:430–7.

14. Kvenshagen B, Jacobsen M, Halvorsen R. Atopic dermatitis in premature and term children. Arch Dis Child. 2009; 94:202–5.

15. Peters AS, Kellberger J, Vogelberg C, Dressel H, Windstetter D, Weinmayr G, et al. Prediction of the incidence, recurrence, and persistence of atopic dermatitis in adolescence: a prospective cohort study. J Allergy Clin Immunol. 2010; 126:590–5.e1–3.

16. Weber AS, Haidinger G. The prevalence of atopic dermatitis in children is influenced by their parents' education: results of two cross-sectional studies conducted in Upper Austria. Pediatr Allergy Immunol. 2010; 21:1028–35.

17. Calder PC. Polyunsaturated fatty acids and cytokine profiles: a clue to the changing prevalence of atopy? Clin Exp Allergy. 2003; 33:412–5.

18. Black PN, Sharpe S. Dietary fat and asthma: is there a connection? Eur Respir J. 1997; 10:6–12.

19. van Zwol A, Moll HA, Fetter WP, van Elburg RM. Glutamine-enriched enteral nutrition in very low birthweight infants and allergic and infectious diseases at 6 years of age. Paediatr Perinat Epidemiol. 2011; 25:60–6.

20. Huurre A, Laitinen K, Rautava S, Korkeamaki M, Isolauri E. Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double-blind placebocontrolled study. Clin Exp Allergy. 2008; 38:1342–8.

21. Duncan JM, Sears MR. Breastfeeding and allergies: time for a change in paradigm? Curr Opin Allergy Clin Immunol. 2008; 8:398–405.

22. Greer FR, Sicherer SH, Burks AW. American Academy of Pediatrics Committee on Nutrition; American Academy of Pediatrics Section on Allergy and Immunology. Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics. 2008; 121:183–91.