1. Karno M, Golding JM, Sorenson SB, Burnam MA. The epidemiology of obsessive-compulsive disorder in five US communities. Arch Gen Psychiatry. 1988; 45:1094–1099. PMID:
3264144.
Article
2. Lee JK. A nationwide epidemiological study of mental disorders in Korea (XIII)-obsessive-compulsive disorder. J Korean Neuropsychiatr Assoc. 1994; 33:5–17.
3. Wolff M, Alsobrook JP 2nd, Pauls DL. Genetic aspects of obsessive-compulsive disorder. Psychiatr Clin North Am. 2000; 23:535–544. PMID:
10986726.
Article
4. Inouye E. Similar and dissimilar manifestations of obsessive-compulsive neuroses in monozygotic twins. Am J Psychiatry. 1965; 121:1171–1175. PMID:
14286051.
5. Carey G, Gottesman II. Klein D, Rabkin J, editors. Twin and family studies of anxiety, phobic, and obsessive disorders. Anxiety: new research and changing concept. 1981. New York: Raven Press;p. 117–136.
6. Clomipramine Collaborative Study Group. Clomipramine in the treatment of patients with obsessive-compulsive disorder. Arch Gen Psychiatry. 1991; 48:730–738. PMID:
1883256.
7. Chouinard G. Sertraline in the treatment of obsessive compulsive disorder: two double-blind, placebo-controlled studies. Int Clin Psychopharmacol. 1992; 7(Suppl 2):37–41. PMID:
1484177.
8. van Grootheest DS, Cath DC, Beekman AT, Boomsma DI. Twin studies on obsessive-compulsive disorder: a review. Twin Res Hum Genet. 2005; 8:450–458. PMID:
16212834.
Article
9. Hemmings SM, Stein DJ. The current status of association studies in obsessive-compulsive disorder. Psychiatr Clin North Am. 2006; 29:411–444. PMID:
16650716.
Article
10. Lewis A. Problems of obsessional illness. Proc Roy Soc Med. 1935; 29:325–336. PMID:
19990606.
Article
11. Rasmussen SA, Tsuang MT. Clinical characteristics and famil history in DSM-III obsessive-compulsive disorder. Am J Psychiatry. 1986; 143:317–322. PMID:
3953865.
12. Riddle MA, Scahill L, King R, Hardin MT, Towbin KE, Ort SI, et al. Obsessive compulsive disorder in children and adolescents: phenomenology and family history. J Am Acad Child Adolesc Psychiatry. 1990; 29:766–772. PMID:
2228931.
Article
13. Bellodi L, Sciuto G, Diaferia G, Ronchi P, Smeraldi E. Psychiatric disorders in the families of patients with obsessive-compulsive disorder. Psychiatry Res. 1992; 42:111–120. PMID:
1631248.
Article
14. Pauls DL, Alsobrook JP, Goodman W, Rasmussen S, Leckman JF. A family study of obsessive-compulsive disorder. Am J Psychiatry. 1995; 152:76–84. PMID:
7802125.
15. Nestadt G, Samuels J, Riddle M, Bienvenu OJ 3rd, Liang KY, LaBuda M, et al. A family study of obsessive-compulsive disorder. Arch Gen Psychiatry. 2000; 57:358–363. PMID:
10768697.
Article
16. Fyer AJ, Lipsitz JD, Mannuzza S, Aronowitz B, Chapman TF. A direct interview family study of obsessive-compulsive disorder. I. Psychol Med. 2005; 35:1611–1621. PMID:
16219119.
Article
17. Lipsitz JD, Mannuzza S, Chapman TF, Foa EB, Franklin ME, Goodwin RD, et al. A direct interview family study of obsessive-compulsive disorder. II. Contribution of proband informant information. Psychol Med. 2005; 35:1623–1631. PMID:
16219120.
Article
18. Nestadt G, Lan T, Samuels J, Riddle M, Bienvenu OJ 3rd, Liang KY, et al. Complex segregation analysis provides compelling evidence for a major gene underlying obsessive-compulsive disorder and for heterogeneity by sex. Am J Hum Genet. 2000; 67:1611–1616. PMID:
11058433.
Article
19. Hanna GL, Fingerlin TE, Himle JA, Boehnke M. Complex segregation analysis of obsessive-compulsive disorder in families with pediatric probands. Hum Hered. 2005; 60:1–9. PMID:
16088199.
Article
20. Cavallini MC, Pasquale L, Bellodi L, Smeraldi E. Complex segregation analysis for obsessive compulsive disorder and related disorders. Am J Med Genet. 1999; 88:38–43. PMID:
10050965.
Article
21. Cavallini MC, Bertelli S, Chiapparino D, Riboldi S, Bellodi L. Complex segregation analysis of obsessive-compulsive disorder in 141 families of eating disorder probands, with and without obsessive-compulsive disorder. Am J Med Genet. 2000; 96:384–391. PMID:
10898919.
Article
22. Alsobrook JP II, Leckman JF, Goodman WK, Rasmussen SA, Pauls DL. Segregation analysis of obsessive-compulsive disorder using symptom-based factor scores. Am J Med Genet. 1999; 88:669–675. PMID:
10581488.
23. Nicolini H, Hanna GL, Baxter T, Schwartz J, Weisbecker K, Spence MA. Segregation analysis of obsessive-compulsive and associated disorders: preliminary results. Ursus Medicus. 1991; 1:25–28.
24. Weissbecker K, Baxter LR, Schwartz JM. Linkage analysis of obsessive-compulsive disorder. Cytogenet Cell Genet. 1989; 51:1105.
25. Hanna GL, Veenstra-VanderWeele J, Cox NJ, Boehnke M, Himle JA, Curtis GC, et al. Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands. Am J Med Genet. 2002; 114:541–552. PMID:
12116192.
Article
26. Willour VL, Yao Shugart Y, Samuels J, Grados M, Cullen B, Bienvenu OJ 3rd, et al. Replication study supports evidence for linkage to 9p24 in obsessive-compulsive disorder. Am J Hum Genet. 2004; 75:508–513. PMID:
15272418.
Article
27. Shugart YY, Samuels J, Willour VL, Grados MA, Greenberg BD, Knowles JA, et al. Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q. Mol Psychiatry. 2006; 11:763–770. PMID:
16755275.
Article
28. Hemmings SM, Kinnear CJ, Niehaus DJ, Moolman-Smook JC, Lochner C, Knowles JA, et al. Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder. Eur Neuropsychopharmacol. 2003; 13:93–98. PMID:
12650952.
Article
29. Marazziti D, Rossi A, Gemignani A, Giannaccini G, Pfanner C, Milanfranchi A, et al. Decreased platelet 3H-paroxetine binding in obsessive-compulsive patients. Neuropsychobiology. 1996; 34:184–187. PMID:
9121618.
30. Zohar J, Insel TR. Obsessive-compulsive disorder: psychobiological approaches to diagnosis, treatment, and pathophysiology. Biol Psychiatry. 1987; 22:667–687. PMID:
3036259.
Article
31. Pigott TA, Zohar J, Hill JL, Bernstein SE, Grover GN, Zohar-Kadouch RC, et al. Metergoline blocks the behavioral and neuroendocrine effects of orally administered m-chlorophenylpiperazine in patients with obsessive-compulsive disorder. Biol Psychiatry. 1991; 29:418–426. PMID:
2018816.
Article
32. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, et al. Allelic variation of human serotonin transporter gene expression. J Neurochem. 1996; 66:2621–2624. PMID:
8632190.
Article
33. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996; 274:1527–1531. PMID:
8929413.
Article
34. McDougle CJ, Epperson CN, Price LH, Gelernter J. Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder. Mol Psychiatry. 1998; 3:270–273. PMID:
9672904.
Article
35. Bengel D, Greenberg BD, Cora-Locatelli G, Altemus M, Heils A, Li Q, et al. Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder. Mol Psychiatry. 1999; 4:463–466. PMID:
10523819.
Article
36. Kinnear CJ, Niehaus DJ, Moolman-Smook JC, du Toit PL, van Kradenberg J, Weyers JB, et al. Obsessive-compulsive disorder and the promoter region polymorphism (5-HTTLPR) in the serotonin transporter gene (SLC6A4): a negative association study in the Afrikaner population. Int J Neuropsychopharmacol. 2000; 3:327–331. PMID:
11343612.
Article
37. Camarena B, Rinetti G, Cruz C, Hernandez S, de la Fuente JR, Nicolini H. Association study of the serotonin transporter gene polymorphism in obsessive-compulsive disorder. Int J Neuropsychopharmacol. 2001; 4:269–272. PMID:
11602033.
Article
38. Frisch A, Michaelovsky E, Rockah R, Amir I, Hermesh H, Laor N, et al. Association between obsessive-compulsive disorder and polymorphisms of genes encoding components of the serotonergic and dopaminergic pathways. Eur Neuropsychopharmacol. 2000; 10:205–209. PMID:
10793323.
Article
39. Walitza S, Wewetzer C, Gerlach M, Klampfl K, Geller F, Barth N, et al. Transmission disequilibrium studies in children and adolescents with obsessive-compulsive disorders pertaining to polymorphisms of genes of the serotonergic pathway. J Neural Transm. 2004; 111:817–825. PMID:
15206000.
Article
40. Chabane N, Millet B, Delorme R, Lichtermann D, Mathieu F, Laplanche JL, et al. Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans. Neurosci Lett. 2004; 363:154–156. PMID:
15172105.
41. Di Bella D, Erzegovesi S, Cavallini MC, Bellodi L. Obsessive-compulsive disorder, 5-HTTLPR polymorphism and treatment response. Pharmacogenomics J. 2002; 2:176–181. PMID:
12082589.
Article
42. Kim SJ, Lee HS, Kim CH. Obsessive-compulsive disorder, factor-analyzed symptom dimensions and serotonin transporter polymorphism. Neuropsychobiology. 2005; 52:176–182. PMID:
16220023.
Article
43. Nakamura M, Ueno S, Sano A, Tanabe H. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry. 2000; 5:32–38. PMID:
10673766.
44. Hu XZ, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD, et al. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet. 2006; 78:815–826. PMID:
16642437.
Article
45. Greenberg BD, Benjamin J, Martin JD, Keuler D, Huang SJ, Altemus M, et al. Delayed obsessive-compulsive disorder symptom exacerbation after a single dose of a serotonin antagonist in fluoxetine-treated but not untreated patients. Psychopharmacology (Berl). 1998; 140:434–444. PMID:
9888619.
Article
46. Hollander E, DeCaria CM, Nitescu A, Gully R, Suckow RF, Cooper TB, et al. Serotonergic function in obsessive-compulsive disorder. Behavioral and neuroendocrine responses to oral m-chlorophenylpiperazine and fenfluramine in patients and healthy volunteers. Arch Gen Psychiatry. 1992; 49:21–28. PMID:
1728249.
47. Enoch MA, Greenberg BD, Murphy DL, Goldman D. Sexually dimorphic relationship of a 5-HT2A promoter polymorphism with obsessive-compulsive disorder. Biol Psychiatry. 2001; 49:385–388. PMID:
11239910.
Article
48. Walitza S, Wewetzer C, Warnke A, Gerlach M, Geller F, Gerber G, et al. 5-HT2A promoter polymorphism-1438G/A in children and adolescents with obsessive-compulsive disorders. Mol Psychiatry. 2002; 7:1054–1057. PMID:
12476319.
49. Meira-Lima I, Shavitt RG, Miguita K, Ikenaga E, Miguel EC, Vallada H. Association analysis of the catechol-o-methyltransferase (COMT), serotonin transporter (5-HTT) and serotonin 2A receptor (5HT2A) gene polymorphisms with obsessive-compulsive disorder. Genes Brain Behav. 2004; 3:75–79. PMID:
15005715.
50. Tot S, Erdal ME, Yazici K, Yazici AE, Metin O. T102C and -1438 G/A polymorphisms of the 5-HT2A receptor gene in Turkish patients with obsessive-compulsive disorder. Eur Psychiatry. 2003; 18:249–254. PMID:
12927326.
Article
51. Nicolini H, Cruz C, Camarena B, Orozco B, Kennedy JL, King N, et al. DRD2, DRD3 and 5HT2A receptor genes polymorphisms in obsessive-compulsive disorder. Mol Psychiatry. 1996; 1:461–465. PMID:
9154247.
52. Graf M. 5-HT2c receptor activation induces grooming behaviour in rats: possible correlations with obsessive-compulsive disorder. Neuropsychopharmacol Hung. 2006; 8:23–28. PMID:
16841562.
53. Cavallini MC, Di Bella D, Pasquale L, Henin M, Bellodi L. 5HT2C CYS23/SER23 polymorphism is not associated with obsessive-compulsive disorder. Psychiatry Res. 1998; 77:97–104. PMID:
9541145.
54. Gross-Isseroff R, Cohen R, Sasson Y, Voet H, Zohar J. Serotonergic dissection of obsessive compulsive symptoms: a challenge study with m-chlorophenylpiperazine and sumatriptan. Neuropsychobiology. 2004; 50:200–205. PMID:
15365215.
Article
55. Stern L, Zohar J, Cohen R, Sasson Y. Treatment of severe, drug resistant obsessive compulsive disorder with the 5HT1D agonist sumatriptan. Eur Neuropsychopharmacol. 1998; 8:325–328. PMID:
9928925.
Article
56. Mundo E, Richter MA, Sam F, Macciardi F, Kennedy JL. Is the 5-HT(1Dbeta) receptor gene implicated in the pathogenesis of obsessive-compulsive disorder? Am J Psychiatry. 2000; 157:1160–1161. PMID:
10873927.
57. Mundo E, Richter MA, Zai G, Sam F, McBride J, Macciardi F, et al. 5HT1Dbeta receptor gene implicated in the pathogenesis of obsessive-compulsive disorder: further evidence from a family-based association study. Mol Psychiatry. 2002; 7:805–809. PMID:
12192628.
58. Camarena B, Aguilar A, Loyzaga C, Nicolini H. A family-based association study of the 5-HT-1Dbeta receptor gene in obsessive-compulsive disorder. Int J Neuropsychopharmacol. 2004; 7:49–53. PMID:
14731309.
59. Di Bella D, Cavallini MC, Bellodi L. No association between obsessive-compulsive disorder and the 5-HT (1Dbeta) receptor gene. Am J Psychiatry. 2002; 159:1783–1785. PMID:
12359689.
60. Lochner C, Hemmings SM, Kinnear CJ, Moolman-Smook JC, Corfield VA, Knowles JA, et al. Corrigendum to "gender in obsessive-compulsive disorder: clinical and genetic findings" [Eur. Neuropsychopharmacol. 14 (2004) 105-113]. Eur Neuropsychopharmacol. 2004; 14:437–445. PMID:
15468463.
61. Nielsen DA, Dean M, Goldman D. Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism. Am J Hum Genet. 1992; 51:1366–1371. PMID:
1463016.
62. Walther DJ, Peter JU, Bashammakh S, Hortnagl H, Voits M, Fink H, et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science. 2003; 299:76. PMID:
12511643.
Article
63. Mossner R, Walitza S, Geller F, Scherag A, Gutknecht L, Jacob C, et al. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder. Int J Neuropsychopharmacol. 2006; 9:437–442. PMID:
16146581.
64. Stein DJ. The neurobiology of obsessive-compulsive disorder. Neuroscientist. 1996; 2:300–305.
Article
65. Goodman WK, McDougle CJ, Price LH, Riddle MA, Pauls DL, Leckman JF. Beyond the serotonin hypothesis: a role for dopamine in some forms of obsessive compulsive disorder? J Clin Psychiatry. 1990; 51(Suppl):36–43. discussion 55-8. PMID:
2199433.
66. Agid O, Lerer B. Risperidone augmentation of paroxetine in a case of severe, treatment-refractory obsessive-compulsive disorder without comorbid psychopathology. J Clin Psychiatry. 1999; 60:55–56. PMID:
10074882.
Article
67. Baker RW, Chengappa KN, Baird JW, Steingard S, Christ MA, Schooler NR. Emergence of obsessive compulsive symptoms during treatment with clozapine. J Clin Psychiatry. 1992; 53:439–442. PMID:
1487472.
68. Vandenbergh DJ, Persico AM, Hawkins AL, Griffin CA, Li X, Jabs EW, et al. Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics. 1992; 14:1104–1106. PMID:
1478653.
Article
69. Miller GM, Madras BK. Polymorphisms in the 3'-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression. Mol Psychiatry. 2002; 7:44–55. PMID:
11803445.
Article
70. Yoo SW, Kim SJ, Kim CH. Association between obsessive-compulsive disorder and dopamine transporter gene polymorphism. Psychiatry Invest. 2006; 3:72–77.
71. Fuke S, Suo S, Takahashi N, Koike H, Sasagawa N, Ishiura S. The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression. Pharmacogenomics J. 2001; 1:152–156. PMID:
11911442.
Article
72. van Tol HH, Wu CM, Guan HC, Ohara K, Bunzow JR, Civelli O, et al. Multiple dopamine D4 receptor variants in the human population. Nature. 1992; 358:149–152. PMID:
1319557.
Article
73. Billett EA, Richter MA, Sam F, Swinson RP, Dai XY, King N, et al. Investigation of dopamine system genes in obsessive-compulsive disorder. Psychiatr Genet. 1998; 8:163–169. PMID:
9800217.
Article
74. Millet B, Chabane N, Delorme R, Leboyer M, Leroy S, Poirier MF, et al. Association between the dopamine receptor D4 (DRD4) gene and obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet. 2003; 116:55–59. PMID:
12497615.
Article
75. Hemmings SM, Kinnear CJ, Lochner C, Niehaus DJ, Knowles JA, Moolman-Smook JC, et al. Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates. Psychiatry Res. 2004; 128:175–182. PMID:
15488960.
Article
76. Kim SJ, Yoo SW, Nam YY, Lee HS, Kim CH. Association between obsessive-compulsive disorder and dopamine receptor D4. Korean J Psychopharmacol. 2005; 16:513–520.
77. Denys D, Van Nieuwerburgh F, Deforce D, Westenberg H. Association between the dopamine D(2) receptor TaqI A2 allele and low activity COMT allele with obsessive-compulsive disorder in males. Eur Neuropsychopharmacol. 2006; 16:446–450. PMID:
16427255.
Article
78. Catalano M, Sciuto G, Di Bella D, Novelli E, Nobile M, Bellodi L. Lack of association between obsessive- compulsive disorder and the dopamine D3 receptor gene: some preliminary considerations. Am J Med Genet. 1994; 54:253–255. PMID:
7810583.
79. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics. 1996; 6:243–250. PMID:
8807664.
Article
80. Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melen K, Julkunen I, et al. Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry. 1995; 34:4202–4210. PMID:
7703232.
Article
81. Karayiorgou M, Altemus M, Galke BL, Goldman D, Murphy DL, Ott J, et al. Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Proc Natl Acad Sci U S A. 1997; 94:4572–4575. PMID:
9114031.
Article
82. Karayiorgou M, Sobin C, Blundell ML, Galke BL, Malinova L, Goldberg P, et al. Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder. Biol Psychiatry. 1999; 45:1178–1189. PMID:
10331110.
Article
83. Schindler KM, Richter MA, Kennedy JL, Pato MT, Pato CN. Association between homozygosity at the COMT gene locus and obsessive compulsive disorder. Am J Med Genet. 2000; 96:721–724. PMID:
11121168.
Article
84. Niehaus DJ, Kinnear CJ, Corfield VA, du Toit PL, van Kradenburg J, Moolman-Smook JC, et al. Association between a catechol-o-methyltransferase polymorphism and obsessive-compulsive disorder in the Afrikaner population. J Affect Disord. 2001; 65:61–65. PMID:
11426511.
Article
85. Erdal ME, Tot S, Yazici K, Yazici A, Herken H, Erdem P, et al. Lack of association of catechol-O-methyltransferase gene polymorphism in obsessive-compulsive disorder. Depress Anxiety. 2003; 18:41–45. PMID:
12900951.
Article
86. Ohara K, Nagai M, Suzuki Y, Ochiai M, Ohara K. No association between anxiety disorders and catechol-O-methyltransferase polymorphism. Psychiatry Res. 1998; 80:145–148. PMID:
9754693.
Article
87. Hotamisligil GS, Breakefield XO. Human monoamine oxidase A gene determines levels of enzyme activity. Am J Hum Genet. 1991; 49:383–392. PMID:
1678250.
88. Sabol SZ, Hu S, Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet. 1998; 103:273–279. PMID:
9799080.
Article
89. Camarena B, Rinetti G, Cruz C, Gomez A, de La Fuente JR, Nicolini H. Additional evidence that genetic variation of MAO-A gene supports a gender subtype in obsessive-compulsive disorder. Am J Med Genet. 2001; 105:279–282. PMID:
11353450.
Article
90. Arnold PD, Rosenberg DR, Mundo E, Tharmalingam S, Kennedy JL, Richter MA. Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study. Psychopharmacology (Berl). 2004; 174:530–538. PMID:
15083261.
Article
91. Delorme R, Krebs MO, Chabane N, Roy I, Millet B, Mouren-Simeoni MC, et al. Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder. Neuroreport. 2004; 15:699–702. PMID:
15094479.
Article
92. Zai G, Arnold P, Burroughs E, Barr CL, Richter MA, Kennedy JL. Evidence for the gamma-amino-butyric acid type B receptor 1 (GABBR1) gene as a susceptibility factor in obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet. 2005; 134:25–29. PMID:
15685626.
Article
93. Hall D, Dhilla A, Charalambous A, Gogos JA, Karayiorgou M. Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. Am J Hum Genet. 2003; 73:370–376. PMID:
12836135.
Article
94. Miguel EC, Leckman JF, Rauch S, do Rosario-Campos MC, Hounie AG, Mercadante MT, et al. Obsessive-compulsive disorder phenotypes: implications for genetic studies. Mol Psychiatry. 2005; 10:258–275. PMID:
15611786.
Article