Korean J Intern Med.  2014 Jan;29(1):31-39. 10.3904/kjim.2014.29.1.31.

Measurement of antioxidant capacity using the biological antioxidant potential test and its role as a predictive marker of metabolic syndrome

• Kim JH
• Baik HW
• Yoon YS
• Joung HJ
• Park JS
• Park SJ
• Jang EJ
• Park SW
• Kim SJ
• Kim MJ
• Jeon DO
• Cho HJ
• Lee SJ
• Im SG
• Jang SK

• KMID: 1792010
• DOI: http://doi.org/10.3904/kjim.2014.29.1.31

Abstract

BACKGROUND/AIMS
Oxidative stress increases the risk of cardiovascular complications of metabolic syndrome (MetS). This study was conducted to examine the difference in antioxidant capacity according to the presence of MetS, and to characterize the association between antioxidant capacity and MetS-related factors.
METHODS
We used the biological antioxidant potential (BAP) test to estimate antioxidant capacity. The BAP test has recently been used as an indicator of antioxidant capacity. We measured BAP levels in 45 patients with MetS (mean age, 44.6 +/- 1.1 years) and 47 age- and sex-matched controls (mean age, 42.7 +/- 1.1 years). To evaluate the association between antioxidant capacity and MetS, adiponectin, high-sensitivity C-reactive protein (hs-CRP), interleukin-6, tumor necrosis factor-alpha, and homeostatic model assessment for insulin resistance (HOMA-IR), linear regression and logistic analyses were performed.
RESULTS
The mean BAP of the MetS group (1,937.3 +/- 36.5 micromol/L) was significantly lower than that of the non-MetS group (2,101.7 +/- 29.5 micromol/L). Also, the mean BAP was low in persons having low high density lipoprotein and high triglyceride. Reduced antioxidant capacity was significantly associated with adiponectin, HOMA-IR and hs-CRP after adjusting for age and sex. The odds ratios for MetS with BAP, log adiponectin, log HOMA-IR, and log hs-CRP were 0.63 (95% confidence interval [CI], 0.49 to 0.82), 0.22 (0.10 to 0.51), 14.24 (4.35 to 46.58), and 1.93 (1.36 to 2.75), respectively.
CONCLUSIONS
Persons with MetS showed reduced antioxidant capacity. We identified relationships between antioxidant capacity measured by BAP test and MetS, as well as MetS-related factors, such as insulin resistance, hs-CRP, and adiponectin.

Keyword

Metabolic syndrome; Oxidative stress; Adiponectin; Insulin

MeSH Terms

Adipokines/blood
Adult
Antioxidants/*metabolism
Biological Markers/blood
C-Reactive Protein/metabolism
Case-Control Studies
Female
Humans
Insulin Resistance
Interleukin-6/blood
Male
Metabolic Syndrome X/*blood
Middle Aged
Predictive Value of Tests
Tumor Necrosis Factor-alpha/blood
Adipokines
Antioxidants
Biological Markers
C-Reactive Protein
Interleukin-6
Tumor Necrosis Factor-alpha