J Korean Med Sci.  2007 Apr;22(2):213-217. 10.3346/jkms.2007.22.2.213.

Advanced Criteria for Clinicopathological Diagnosis of Food Protein-induced Proctocolitis

• Hwang JB
• Park MH
• Kang YN
• Kim SP
• Suh SI
• Kam S

• KMID: 1713165
• DOI: http://doi.org/10.3346/jkms.2007.22.2.213

Abstract

The clinicopathological findings in previous studies concerning food protein-induced proctocolitis (FPIPC) are quite diverse in terms of results and conclusions. The aim of this study was to suggest advanced clinicopathological diagnostic criteria that facilitate the early confirmation of FPIPC. Data of 38 FPIPC patients, who had received sigmoidoscopy and biopsy, was analyzed. Microscopic findings were compared with observations of previous studies. Feeding at onset of bleeding was exclusively breast-fed (94.7%) and formula-fed or mixed-fed (5.3%). Endoscopic abnormalities were observed in all patients; nodular hyperplasias with circumscribed and/or central pit-like erosions in 94.7% and erythema in 5.3%. Histopathological findings were; lymphoid aggregates in 94.7%, eosinophils in lamina propria of > or =60 cells/10 HPF in 97.4% and of >20 cells/HPF in 63.2%, epithelial or muscularis mucosa eosinophil infiltration in 97.4%, and crypt abscess in 2.6%. The majority of FPIPC patients are exclusively breast-fed and nodular hyperplasias with erosions may be a disease specific endoscopic finding. Histologic diagnosis of FPIPC is compatible with eosinophils in the lamina propria of > or =60 cells/10 high power fields; however, >20 cells/HPF is not an appropriate diagnostic criterion.

Keyword

Food protein-induced proctocolitis; Breast feeding; Endoscopic; Nodular hyperplasia; Histopathological

MeSH Terms

Sensitivity and Specificity
Reproducibility of Results
Rectal Diseases/*diagnosis/etiology
Proctocolitis/*diagnosis/*etiology
Male
Infant, Newborn
Infant
Humans
Gastrointestinal Hemorrhage/*diagnosis/etiology
Female
Dietary Proteins/*adverse effects
Diagnosis, Differential
Breast Feeding/*adverse effects

Figure

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  Fig. 1 Sigmoidoscopy shows nodular hyperplasias with circumscribed (A) and/or central pit-like erosions (B) in the patients with food protein-induced proctocolitis. Nodular hyperplasias are prominent in an endoscopically deflated state (C).

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