J Korean Ophthalmol Soc.  2008 Dec;49(12):1935-1940.

Long-term Effect of Intravitreal Bevacizumab for CNV Secondary to Age-Related Macular Degeneration

Affiliations
  • 1Department of Ophthalmology, KyungHee University College of Medicine, Seoul, Korea. hwkwak@khmc.or.kr

Abstract

PURPOSE: To investigate the long-term therapeutic effect and safety of repeated intravitreal bevacizumab injections for managing choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).
METHODS
Clinical data of 14 eyes of 14 patients who were treated with repeated (3 times or more) intravitreal bevacizumab injections for secondary to AMD and followed up for 12 months were collected. Patients were treated with 1.25 mg of intravitreal bevacizumab. Bevacizumab was injected at 6-week intervals. Reinjection was performed with the same method according to the physician's decision.
RESULTS
Mean visual acuity change increased by 4.0 lines from 1.13+/-0.47 to 0.73+/-0.44 (LogMAR). Mean central retinal thickness change decreased by 114.8 micrometer from 240.3+/-123.8 micrometer to 125.5+/-39.4 micrometer. Visual acuity improved statistically significantly at 12 weeks after first intravitreal bevacizumab injections and was maintained for 12 months. Central retinal thickness decreased statistically significantly at 6 weeks after the first intravitreal bevacizumab injection and was maintained for 12 months. During the 12 months of 4 intravitreal bevacizumab injections, mean visual acuity change increased by 4.0 lines at 12 months and 4.4 lines at 7 months.
CONCLUSIONS
Intravitreal bevacizumab injection causes a significant decrease in central retinal thickness and improvement in visual acuity in eyes with CNV due to AMD for 12 months.

Keyword

Age-related macular degeneration; Avastin; Bevacizumab; Choroidal neovascularization; Optical coherence tomography

MeSH Terms

Antibodies, Monoclonal, Humanized
Choroidal Neovascularization
Eye
Humans
Macular Degeneration
Retinaldehyde
Tomography, Optical Coherence
Visual Acuity
Bevacizumab
Antibodies, Monoclonal, Humanized
Retinaldehyde

Figure

  • Figure 1 . Mean (±SD) change in visual acuity letter scores through 48 weeks (5 letters=1 line).

  • Figure 2 . Change in central retinal thickness from baseline to 48 weeks in all treated eyes.


Reference

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