J Korean Soc Neonatol.  2003 Nov;10(2):133-142.

Recent Outcome of Extremely Low Birth Weight Infants at Asan Medical Center

Affiliations
  • 1Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. kskim@amc.seoul.kr

Abstract

PURPOSE
Survival rate of infants weighing less than 1, 000 g has been increased due to advanced neonatal care. We evaluated the outcome of extremely low birth weight (ELBW) infants who were born at Asan Medical Center. METHODS: We retrospectively reviewed survival, morbidities, and catch-up growth of the 105 ELBW infants from 1999 to 2002. RESULTS: Overall survival rate of ELBW infants was 65.7%. In respect to birth weight, the survival rates for <600 g, 600-699 g, 700-799 g, 800-899 g, 900-999 g were 22.2%, 38.5%, 64.3%, 70.4%, 89.3%, respectively. According to gestational age, <25 week, 25-27 week, 28-30 week, 31-33 weeks by gestational age, the survival rates were 26.7%, 68.3%, 76.9%, 100%, respectively. The mortality was 41.7% within one week of life. Among ELBW survivors, durations of hospitalization, O2 supply, and ventilatory support were 92.2+/-23.9 day, 36.9 +/- 26.5 day, 24.8 +/- 20.3 day, respectively. The incidences of respiratory distress syndrome, chronic lung disease and patent ductus arteriosus were 52.2%, 68.1%, 47.8%, respectively. The incidences of severe intraventricular hemorrhage > or = grade III, periventricular leukomalacia, severe retinopathy of prematurity > or = stage III and clinical or proven sepsis were 8.7%, 4.3%, 47.8%(n=33), 69.6%, respectively. 29 infants required laser photocoagulation due to retinopathy of prematurity. Duration of total parenteral nutrition (TPN) was 44.0 +/- 22.3 days. The incidences of TPN-associated cholestasis and necrotizing enterocolitis were 34.8%, 7.2%, repectively. At 18 months, 78.3% of ELBW infants showed catch-up growth. CONCLUSION: Survival rate of ELBW infants was 65.7%, which was much improved but lower than that of western and Japanese outcome. Further efforts must be made to increase their survival rates and to reduce morbidities.

Keyword

Extremely low birth weight (ELBW); Survival rate; Morbidity

MeSH Terms

Asian Continental Ancestry Group
Birth Weight
Cholestasis
Chungcheongnam-do*
Ductus Arteriosus, Patent
Enterocolitis, Necrotizing
Gestational Age
Hemorrhage
Hospitalization
Humans
Incidence
Infant*
Infant, Low Birth Weight*
Infant, Newborn
Leukomalacia, Periventricular
Light Coagulation
Lung Diseases
Mortality
Parenteral Nutrition, Total
Retinopathy of Prematurity
Retrospective Studies
Sepsis
Survival Rate
Survivors
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