J Korean Soc Neonatol.  2002 May;9(1):12-20.

The Changes of Incidence of Nosocomial Sepsis, and Risk Factors in Extremely Low Birth Weight Infants

• Kim BL
• Whang JH
• Kang CK
• Sim JW
• Kim SS
• Chang YS
• Park WS
• Choi ES

Abstract

PURPOSE: To know whether the changes in the risk factors of nosocomial sepsis had an impact on the occurrence of nosocomial sepsis (NS) in extremely low birth weight infants (ELBW I).
METHODS
ELBW I who were admitted to the NICU at Samsung Medical Center from October 1994 to December 2000 were devided into three groups according to periods (period I:1994.10-1996.9, period II:1996.10-1998.12, period III:1999.1-2000.12), and charts were reviewed retrospectively for demographic profile, incidence of NS, and changing patterns of risk factors of NS.
RESULTS
Gestational age and birth weight of ELBW I decreased and the incidence of NS increased significantly during third period. However, cumulative incidence of NS corrected by hospital days was not changed irrespective of periods. Among the risk factors of NS in 3rd period, use of antibiotics in the 1st day, postnatal dexamethasone and use and duration of indwelling umbilical catheters decreased significantly and the use of nasal continuous positive airway pressure increased significantly especially, in ELBW I under 800 g of birth weight. In the ELBW I under 800 g of birth weight, cumulative incidence of NS and mortality among the infants who suffered from NS decreased significantly in 3rd period.
CONCLUSION
Efforts to decrease the risk factors of NS can prevent the increase in incidence of NS in ELBW I.

Keyword

Extremely low birth weight infant; Nosocomial sepsis; Risk factors

MeSH Terms

Anti-Bacterial Agents
Birth Weight
Catheters
Continuous Positive Airway Pressure
Dexamethasone
Gestational Age
Humans
Incidence*
Infant*
Infant, Extremely Low Birth Weight
Infant, Low Birth Weight*
Infant, Newborn
Mortality
Retrospective Studies
Risk Factors*
Sepsis*
Anti-Bacterial Agents
Dexamethasone