J Korean Rheum Assoc.  2008 Mar;15(1):92-95. 10.4078/jkra.2008.15.1.92.

A Case of Pachydermodactyly

• Kim HS
• Jun JB
• Park CG
• Lee CW
• Joo KB

• KMID: 1324516
• DOI: http://doi.org/10.4078/jkra.2008.15.1.92

Abstract

Pachydermodactyly is a kind of benign fibromatosis in which asymptomatic symmetrical soft tissue swellings occur on the proximal phalanges and the proximal interphalangeal joints of the hands. Although young women can also be affected, the young men are affected most commonly. There is no bony or articular abnormality on radiographic study. Histological examination of skin demonstrated epidermal hyperplasia, hyperkeratosis, acanthosis and thickened reticular dermis by deposition of collagen. It is important to recognize this disease identity without misdiagnosis for other rheumatologic diseases to avoid inappropriate and possibly toxic treatments. We report a case of pachydermodactyly and discuss the differential diagnosis.

Keyword

Pachydermodactyly; Knuckle pads; Pachydermoperiostosis

MeSH Terms

Female
Male
Humans
Diagnosis, Differential

Figure

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  Fig. 1. Hand picture showed symmetrical fusiform swellings around the proximal interphalangeal joints.

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  Fig. 2. Hand X-ray showed soft tissue swelling around the proximal interphalangeal joints and normal underlying bone.

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  Fig. 3. Magnetic resonance imaging showed fusiform soft tissue swelling around the proximal interphalangeal joints without joint effusion, synovial hypertrophy, and bony abnormality.

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  Fig. 4. (A) H-E stain showed reticular dermis thickened by deposit of collagen (×100). (B) Alcian blue stain showed deposition of mucin (×100).

Reference

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